Associate Scientist II, CNS

Associate Scientist II, CNS

Company Name: Alnylam Pharmaceuticals

Overview

The Research Department at Alnylam is seeking a motivated Associate Scientist II to join our team to support the CNS (Central Nervous System) Delivery group in the receiving and storage of nonclinical compounds samples. We are seeking a highly organized individual that is able to work quickly and efficiently in a fast-paced laboratory setting. This Associate Scientist II must collaborate on a team and coordinate tasks with various stakeholders to ensure deadlines are met.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Contribute to study design and execution of studies to characterize molecules for RNAi therapeutic programs, including rodent disease models
• Develop and conduct assays such as qPCR, western blot, and hELISA, that support in vivo studies
• Perform in vivo procedures in rodents, including administration of therapeutics via established methodologies
• Analyze and interpret the data
• Prepare clearly articulated experimental reports and data presentations
• Prepare of SOPs/protocols
• Present data to groups within and outside of Research
• Maintain database of samples used for nonclinical studies ensuring accurate and prompt storage of samples
• Track samples in databases including but not limited to Electronic Laboratory Notebook (ELN), Laboratory Information Management System (LIMS), Smart Refrigeration systems, Smartsheet’s and other proprietary databases.
• Support preparation of nonclinical tissue samples (i.e. weighing, grinding, and lysis) to extract target siRNA for downstream analysis
• Complete assignments in a timely and clearly documented manner
• Handle tasks quickly and efficiently in a fast-paced work environment
• Communicate openly and directly with lab group in order to provide sufficient solutions that will work for all team members

Qualifications

• Minimum B.S. degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, or Genetics
• 1+ years of experience in laboratory research
• Basic rodent in vivo skills (animal handling, subcutaneous/intravenous dosing, blood collection, and necropsy/dissection expertise)
• Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s)
• Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports
• Must be flexible, open to new tasks and challenges and able to work on tight deadlines
• Exceptional interpersonal skills and the ability to function in a high capacity within a fast-paced team environment.
• Excellent attention to detail, organizational skills, eagerness to learn, and the ability to follow written and verbal instruction.
• Working knowledge of standard Microsoft Office applications including Excel, Outlook, PowerPoint, and Word.
• Experience with purification and quantification of RNA, including qPCR assay, is a plus.

About Alnylam

Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture

Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.