Job Description:

OBJECTIVES/PURPOSE

Design and implement experiments to screen for drug candidates and to address mechanisms-of-action of therapeutic molecules. Perform complex cell-based functional experiments independently. Act as a subject matter expert (SME) for drug discovery in the Cell therapy and Immuno-Oncology/Immuno-Therapy.

Accountabilities

Provide broad assay development support for early-stage drug discovery projects in disease areas of the Cell therapy Design, execute, and validate a variety of assays to understand mechanisms of action and characterize CAR T Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of variable cell-based assays. CAR T generation (transduction and expansion) and functional evaluation of CAR expression, phenotyping, cytokine detection and killing potency in vitro. Spend ~ 85% of time in the laboratory to maintain and implement cell cell-based assay platform and perform experiments Interface with project teams to meet timelines for project progression Present research findings clearly and effectively at internal and external meetings Troubleshoot complex problems in creative and effective ways Ability to manage workflow to deliver quality results in a timely manner Troubleshoot complex problems in creative and effective ways and actively participates in innovation and/or optimization of established processes to ensure data relavence and quality  Ability to make data-driven influences on project decision-making

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS :

Master's degree in cell immunology, protein/antibody science, and/or >3 years equivalent relevant work experience with strong knowledge of T/NK cell biology, immuno-oncology, and cell therapy. Bachelor’s degree with >6 years relevant experience. Tissue culture, including application of aseptic techniques for media compounding, passaging, maintenance, and cryopreservation of cell cultures. Experience with immune cell (T/NK cells) isolation, culture, and engineering. Proficiency in immune cell phenotyping (surface/intracellular), cytokine detection (multi-color flow cytometry, Luminex, MSD), cytotoxicity assay (short or long term killing), internalization assay and High content imaging (Opera Phenix) or other functional assays. Proficient in data generation (Prism, Excel), presentation, and troubleshooting. Experience with viral delivery methods is a plus. Knowledgeable and experienced in cell biology and antibody characterization Experience in troubleshooting, assay optimization and data quality control is a plus Skilled in data analysis, interpretation, and data reporting Hands-on cell-based functional assay experience

Takeda Compensation and Benefits Summary:

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range :

$99,500.00 - $156,420.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement:

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations:

Boston, MA

Worker Type:

Employee

Worker Sub-Type:

Regular

Time Type:

Full time

Job Exempt:

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.