Associate Scientist

Role Summary

Associate Scientist

Responsibilities

• Spearhead the development and deployment of high-throughput platforms to accelerate early discovery of engineered Œ≥Œ¥T cell therapies.
• Establish scalable workflows using automated liquid handling and high-content imaging platforms to streamline construct screening across primary donor sources.
• Implement robotic protocols for cell isolation, transduction, and expansion in 96 & 384 well formats, to enable parallel testing of CAR variants with consistent throughput and reproducibility.
• Execute high-throughput screening of antibody discovery campaigns to identify lead candidates for CAR binder design and optimization.
• Perform high-throughput array-based pooled screening to evaluate novel CAR signaling domain constructs for functional activity.
• Design, execute, and optimize high throughput screening in vitro assays for lead hit identification‚Äîincluding cytokine profiling, 2D/3D cytotoxicity, and phenotypic flow cytometry.
• Collaborate with automation engineers and data scientists to troubleshoot workflow issues, validate assay performance, and drive seamless integration of experimental outputs into global systems.
• Develop standardized SOPs, defined QC metrics, and contribute to global harmonization efforts to support assay transferability and alignment across biologics and cell therapy pipelines.
• Mentor junior scientists, manage laboratory resources, and coordinate cross-functional project timelines within a matrixed team structure.
• Present key findings to cross-functional stakeholders to support early go/no-go decisions and alignment with pipeline strategy and IND-enabling milestones.

Qualifications

• Required: Master‚Äôs of Biology, Biotechnology degree or related field plus 3 years of related experience OR Bachelor‚Äôs of Biology, Biotechnology degree or related field plus 5 years of related experience.
• Required: Prior experience must include design and execute experiments to assess anti-tumor functionality of allogeneic innate CAR cell therapies (e.g. Cord blood derived CAR-NK, CAR-gdT), including analysis of cytokine, cytotoxicity assays, and repeat antigen stimulation.
• Required: perform cell isolation, activation, transduction, expansion, and cryopreservation of PBMC-derived CAR-T cells for functional characterization; exposure to automated or semi-automated liquid handling for in vitro functional assay setup; perform cell isolation, activation, transduction, expansion, and cryopreservation of cord-blood derived NK cells, ensuring high viability and functionality.
• Required: perform gamma retroviral vector production and retroviral transduction of innate immune cells (e.g. NK or gdT); conduct multiparameter flow cytometry (8+ color) to characterize immune phenotypes; cell culture, immunofluorescence imaging & plasmid cloning.

Education

• Biology or Biotechnology degree (as applicable per above qualifications).

Additional Requirements

• Locations: Boston, MA
• Work type: Full time