Associate Scientist, Cell Therapy

Role Summary

Associate Scientist, Cell Therapy is responsible for laboratory activities related to the research and development of CRISPR/Cas9 genome edited and mRNA-CAR T cell therapies for oncology and autoimmune disorders. You will work alongside teammates to execute experiments to assess and optimize delivery of cargo to immune cells and test for functionality in vitro and in vivo. The candidate will support the team by performing in-vivo studies using murine models to evaluate therapeutic efficacy and will collaborate within a matrixed organization to improve understanding of CAR T cell, mRNA, and LNP biology.

Responsibilities

• Perform in-vitro assays to quantify cargo delivery to T-cells and perform immunoassays (cytotoxicity and cytokine release) to evaluate potency and specificity of engineered T cells.
• Conduct in-vivo studies using murine models to evaluate therapeutic efficacy.
• Collaborate within a matrixed organization to improve understanding of CAR T cell, mRNA, and LNP biology.

Qualifications

• Required: Master‚Äôs degree in Biological Sciences, Bioengineering, Medical Biotechnology, or a directly related field and at least two years of laboratory experience in industry. Alternatively, Bachelor‚Äôs degree plus at least four years of laboratory experience in industry will be considered.
• Experience culturing and manipulation of human T cells or PBMCs
• Experience with multi-color flow cytometry of T cells with up to 6 markers
• Experience with in-vitro T cell assays including cytokine quantification (ELISA or MSD), and cell-based cytotoxicity assays with tumor cell lines
• Animal handling experience, including intravenous, intraperitoneal, and subcutaneous injections and animal model development
• Processing animal tissues and organs (e.g., spleen) to single cell suspension for downstream analysis

Education

• Master‚Äôs degree in Biological Sciences, Bioengineering, Medical Biotechnology, or a directly related field; or Bachelor‚Äôs degree with at least four years of laboratory experience in industry.