Associate Scientist, Biomaterials
United Therapeutics Corporation
5 months ago
On-site
Manchester, NH
Clinical Research and Development
Responsibilities:
- Optimize and perform peptide/protein conjugation studies on 3D printed hydrogel scaffolds
- Develop and optimize analytical assays for quantification of peptides/proteins conjugated on 3D printed hydrogel scaffolds
- Develop and optimize analytical assays for peptide/protein quantification to assess QC metrics
- Assist with post-processing workflow (primarily surface modification) for 3D printed hydrogel scaffolds
- Develop and perform assays to study peptide/protein stability at multiple storage and sampling conditions
- Identify strategies to improve peptide/protein conjugation efficiency on 3D printed hydrogel scaffolds
- Develop and evaluate robust approaches to enhance cell interactions with novel bio-inks
- Assist with basic project management (project plan and schedule)
- Generate comprehensive protocols for testing/analyzing materials during development
- Provide support in fluidic system optimization and improvement
- Generate design assurance and report documentation for testing and characterization
- Collaborate with biomedical and mechanical engineering teams
- Provide expertise in surface modification, cross-linking, and coatings for differential material interfaces and luminal surfaces contacting cells
- Serve as point of contact for internal cross-functional R&D teams and external vendors/consultants
- Conduct and interpret lab work and prototype performance testing; guide bio-ink design iterations
- Recommend new directions based on data and program objectives/goals
- Maintain knowledge of emerging technology in biomaterials, polymer chemistry, and bio-ink
Minimum Requirements:
- 3+ years engineering R&D experience with a Master’s degree in chemistry, materials, surface science, polymer chemistry, chemical engineering, biomedical engineering, coatings, or drug delivery (co-op/intern experience acceptable)
- Knowledge of fundamentals in organic chemistry
- Basic understanding of chromatographic methods
- Proven success (products and/or publications) in polymer chemistry and surface functionalization with polymers or monolayers
- Proficient in MS Office (Word, Excel, Outlook, PowerPoint)
- Experience with aseptic technique and mammalian cell culture
Preferred Qualifications:
- PhD in relevant fields (chemistry, materials, surface science, polymer chemistry, chemical engineering, biomedical engineering, coatings, drug delivery)
- Experience working with peptides
- Experience with analytical systems: rheometer and Instron
- Experience in 3D printing hydrogel
Benefits:
- Medical/dental/vision/prescription coverage; employee wellness resources; 401(k) and ESPP; paid time off and paid parental leave; disability benefits and more
Location:
- On-site, full-time in Manchester, New Hampshire
- Optimize and perform peptide/protein conjugation studies on 3D printed hydrogel scaffolds
- Develop and optimize analytical assays for quantification of peptides/proteins conjugated on 3D printed hydrogel scaffolds
- Develop and optimize analytical assays for peptide/protein quantification to assess QC metrics
- Assist with post-processing workflow (primarily surface modification) for 3D printed hydrogel scaffolds
- Develop and perform assays to study peptide/protein stability at multiple storage and sampling conditions
- Identify strategies to improve peptide/protein conjugation efficiency on 3D printed hydrogel scaffolds
- Develop and evaluate robust approaches to enhance cell interactions with novel bio-inks
- Assist with basic project management (project plan and schedule)
- Generate comprehensive protocols for testing/analyzing materials during development
- Provide support in fluidic system optimization and improvement
- Generate design assurance and report documentation for testing and characterization
- Collaborate with biomedical and mechanical engineering teams
- Provide expertise in surface modification, cross-linking, and coatings for differential material interfaces and luminal surfaces contacting cells
- Serve as point of contact for internal cross-functional R&D teams and external vendors/consultants
- Conduct and interpret lab work and prototype performance testing; guide bio-ink design iterations
- Recommend new directions based on data and program objectives/goals
- Maintain knowledge of emerging technology in biomaterials, polymer chemistry, and bio-ink
Minimum Requirements:
- 3+ years engineering R&D experience with a Master’s degree in chemistry, materials, surface science, polymer chemistry, chemical engineering, biomedical engineering, coatings, or drug delivery (co-op/intern experience acceptable)
- Knowledge of fundamentals in organic chemistry
- Basic understanding of chromatographic methods
- Proven success (products and/or publications) in polymer chemistry and surface functionalization with polymers or monolayers
- Proficient in MS Office (Word, Excel, Outlook, PowerPoint)
- Experience with aseptic technique and mammalian cell culture
Preferred Qualifications:
- PhD in relevant fields (chemistry, materials, surface science, polymer chemistry, chemical engineering, biomedical engineering, coatings, drug delivery)
- Experience working with peptides
- Experience with analytical systems: rheometer and Instron
- Experience in 3D printing hydrogel
Benefits:
- Medical/dental/vision/prescription coverage; employee wellness resources; 401(k) and ESPP; paid time off and paid parental leave; disability benefits and more
Location:
- On-site, full-time in Manchester, New Hampshire