Associate Scientist, Biology

Job Description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Wave is seeking an experienced and highly motivated biologist to join its research team in Cambridge, Massachusetts. This is an ideal position for an individual with a strong background in drug discovery and early drug development who thrives in a team-oriented, fast-paced, and cross-disciplinary biotech environment. This successful candidate will contribute to all levels of discovery research to support the development of optimized nucleic acid therapies for neuromuscular disorders.

Experience

• Bachelor’s degree in a relevant scientific discipline (e.g., Biology, Biochemistry, Neuroscience) with 3–4 years of research experience, or a Master’s degree with 1–2 years of post-graduate research experience

Responsibilities

• Design, execute, and analyze molecular biology and pharmacology experiments to support the advancement of therapeutic programs and discovery research platforms targeting neuromuscular diseases
• Develop and optimize in vitro assays, including cell culture, high-throughput screening, next-generation sequencing (NGS), quantitative PCR (qPCR), protein quantification and analysis, induced pluripotent stem cell (iPSC) differentiation, and imaging-based cell functional assays
• Perform in vivo sample processing and execute pharmacodynamic studies to evaluate the efficacy and mechanism of candidate therapeutics
• Demonstrate strong experimental design skills, efficient assay development, and creative problem-solving abilities to address technical challenges in drug discovery
• Collaborate with multidisciplinary teams to present, discuss, and troubleshoot experimental outcomes, supporting the preclinical evaluation of oligonucleotides therapeutic modalities

Key Skills

• Demonstrated expertise in cell culture techniques, including maintenance and differentiation of iPSC-derived neurons, myoblasts, and primary cell cultures
• Proficient in molecular biology and biochemistry techniques, such as qPCR, ELISA, MSD, Western blot, and high-throughput automation platforms
• Demonstrated ability to plan and organize experiments effectively, adapt to changing priorities, and a strong desire to learn new techniques
• Hands-on experience in drug discovery research for neuromuscular diseases, including target validation, assay development, and preclinical evaluation, is strongly preferred
• Experience with in vitro neuronal function and high-content imaging assays is preferred
• Prior research experience in neurodegenerative diseases or neuromuscular diseases is strongly preferred
• Familiarity with NGS methods and oligonucleotide therapeutics is a plus

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.