Associate Scientist
Cytokinetics
4 hours ago
On-site
San Francisco Bay Area
Clinical Research and Development
Key Responsibilities
- Design, execute, and manage in vivo pharmacology studies and downstream biochemical and molecular assays to evaluate the efficacy of small-molecule therapeutics for cardiac indications.
- Lead day-to-day oversight of animal study cohorts, including scheduling, dosing, monitoring, and coordination with vivarium staff, ensuring full compliance with IACUC and institutional guidelines.
- Quantify and interpret biomarkers of disease progression and target engagement, integrating functional and molecular endpoints to assess compound performance.
- Collaborate closely with discovery, DMPK, and translational teams to advance compounds through preclinical development, contributing to study design, data interpretation, and go/no-go decisions.
- Maintain rigorous documentation of experimental methods and results; manage datasets; prepare clear, concise data summaries and presentations for internal project team meetings and program reviews.
Qualifications
- BS in Biology, Physiology, Pharmacology, or a related discipline with 8+ years of hands-on research experience or MS with 6+ years of experience; prior experience in a pharmaceutical or biotechnology setting strongly preferred.
- Demonstrated proficiency in rodent handling and dosing (mouse and rat), including multiple routes of administration.
- Experience with cardiac functional assessments (e.g., echocardiography, tail-cuff blood pressure measurements, or related techniques) highly desirable.
- Extensive hands-on experience in biochemical and molecular biology assays, such as Western blotting, qPCR, immunohistochemistry, and enzyme-based assays.
- Experience with handling mammalian cell culture or primary cardiomyocytes is a plus.
- Ability to analyze, interpret, and clearly communicate complex datasets in written reports and oral presentations.
- Design, execute, and manage in vivo pharmacology studies and downstream biochemical and molecular assays to evaluate the efficacy of small-molecule therapeutics for cardiac indications.
- Lead day-to-day oversight of animal study cohorts, including scheduling, dosing, monitoring, and coordination with vivarium staff, ensuring full compliance with IACUC and institutional guidelines.
- Quantify and interpret biomarkers of disease progression and target engagement, integrating functional and molecular endpoints to assess compound performance.
- Collaborate closely with discovery, DMPK, and translational teams to advance compounds through preclinical development, contributing to study design, data interpretation, and go/no-go decisions.
- Maintain rigorous documentation of experimental methods and results; manage datasets; prepare clear, concise data summaries and presentations for internal project team meetings and program reviews.
Qualifications
- BS in Biology, Physiology, Pharmacology, or a related discipline with 8+ years of hands-on research experience or MS with 6+ years of experience; prior experience in a pharmaceutical or biotechnology setting strongly preferred.
- Demonstrated proficiency in rodent handling and dosing (mouse and rat), including multiple routes of administration.
- Experience with cardiac functional assessments (e.g., echocardiography, tail-cuff blood pressure measurements, or related techniques) highly desirable.
- Extensive hands-on experience in biochemical and molecular biology assays, such as Western blotting, qPCR, immunohistochemistry, and enzyme-based assays.
- Experience with handling mammalian cell culture or primary cardiomyocytes is a plus.
- Ability to analyze, interpret, and clearly communicate complex datasets in written reports and oral presentations.