Associate Scientist, Assay Development

Role Summary

Associate Scientist, Assay Development at Pfizer’s BioMedicine Design group. The role focuses on establishing binding and functional assays and supporting hit-to-lead discovery of peptide and antibody-based therapeutics. You will design and execute biochemical and cell-based assays, perform high-throughput screening, analyze data, and collaborate with project teams to identify lead molecules.

Responsibilities

• Develop assays to identify and characterize peptide, antibody and multispecific candidates to support programs across multiple therapeutic areas. Biochemical assay formats may include protein binding, competition and enzymatic cleavage assays. Cell based assays may include binding (FACS and ELISA), competition, cell signaling (NanoBiT, calcium flux, cAMP, phospho-protein HTRF/AlphaLISA, etc) and reporter gene assays using a variety of cell lines.
• Execute high-throughput screens using automated and semi-automated platforms and analyze results.
• Collaborate with project teams to establish screening strategies, interpret results, and make decisions to drive programs forward.
• Write protocols, maintain electronic lab notebook, and regularly review literature to maintain knowledge of scientific trends and new technologies.

Qualifications

• Required: Bachelor’s degree and 0-3 years of experience in molecular biology, biochemistry, cell biology or related discipline, along with a basic understanding of biologics drug discovery workflows.
• Required: Demonstrated experience in assay development and troubleshooting with methods such as HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity.
• Required: Demonstrated experience with plate-based assay formats and maintaining cell cultures.
• Required: Track record of strong problem solving and organizational skills, attention to detail, and ability to multi-task.
• Required: Strong written and oral communication skills.
• Preferred: Experience with Tecan or Beckman liquid handling platforms; experience with high content imaging and multiplex assay formats; experience writing scripts to automate data processing or other coding experience.

Additional Requirements

• Physical/Mental Requirements: Requires work in BL2 laboratory environment with appropriate PPE.
• Work Location Assignment: On Premise.
• Last Day to Apply: January 22, 2026.