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Associate Scientist

Crinetics Pharmaceuticals
Full-time
On-site
San Diego, CA
$107,000 - $134,000 USD yearly

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Role Summary

The Associate Scientist, In Vivo Pharmacology will work collaboratively and be responsible for performing a variety of pre-clinical in vivo experiments to support projects at various stages of development in endocrine disorders and endocrine-related cancers.

Responsibilities

  • Design and conduct pre-clinical in vivo experiments to evaluate the pharmacodynamics, pharmacokinetics, and safety of therapeutic candidate molecules.
  • Develop new animal models for evaluating novel small molecules for endocrine diseases.
  • Demonstrate initiative to troubleshoot and accurately perform in vivo studies.
  • Ensure care and welfare of laboratory animals in accordance with regulations and IACUC protocols.
  • Generate and manage purchase orders, contracts, and other related documents.
  • Present findings at team and departmental meetings.
  • Perform animal husbandry to conduct biological assays.
  • Run and troubleshoot biomarker assays (e.g., ELISAs, LUMINEX assays).
  • Analyze experimental data using MS Office, PRISM or comparable software.
  • Comply with established practices and procedures, including notebooks, files, quality/regulatory guidelines, and safety standards.
  • Other duties as assigned.

Qualifications

  • Required: Bachelor’s in Biology, Pharmacology, Neuroscience, Toxicology or related discipline with a minimum of 8 years of relevant experience, or Master’s degree with a minimum of 6 years of relevant experience.
  • Proven hands-on proficiency in rodent handling and in vivo skills including dosing (IV, PO, SC), blood and tissue collection, necropsy, and designing/conducting rodent in vivo pharmacology studies.
  • Experience with ELISA and biomarker assays.
  • Proficient in basic surgical techniques in rodents.
  • Ability to follow established experimental designs and develop new methods as needed.
  • Strong communication and presentation skills; excellent organizational skills and attention to detail; ability to troubleshoot.
  • Strong work ethic and ability to multitask and be enthusiastic about animal and laboratory work.

Skills

  • In vivo pharmacology
  • Rodent handling and dosing
  • Biomarker assays (ELISA, LUMINEX)
  • Data analysis (MS Office, PRISM)
  • Surgical techniques in rodents

Education

  • Bachelor’s in Biology, Pharmacology, Neuroscience, Toxicology or related discipline (required) or Master’s degree (required) with corresponding experience.

Additional Requirements

  • Travel up to 5% of time.
  • Physical demands involve occasional lifting up to 25 lbs and standing/often at a desk as part of laboratory work.