Associate Scientific Director, Pharmacometrics

What You’ll Do
- Provide pharmacometrics expertise to activities throughout the drug development lifecycle and collaborate with cross-functional teams
- Execute advanced pharmacometrics analyses (PK/PD modeling and simulation; exposure-response analysis) for high-priority programs
- Identify opportunities where modeling and simulation advance understanding of pharmacokinetics, pharmacodynamics, efficacy, and safety
- Contribute to Model Informed Drug Development (MIDD) for dose selection, regimen optimization, and clinical trial design
- Communicate pharmacometrics results to program teams to support data-driven decision-making
- Mentor and guide Clinical Pharmacology and Pharmacometrics colleagues on analysis methodologies
- Serve as lead author/key contributor for pharmacometrics sections of clinical and regulatory documents
- Publish in scientific journals and present at internal/external scientific events

Qualifications
Required
- PhD in Pharmacology, Pharmacokinetics, Pharmaceutics, or a related quantitative discipline
- 5+ years industry experience applying population PK/PD and other advanced quantitative methodologies to decision-making
- Deep and extensive experience with advanced population PK/PD methodology
- Strong clinical pharmacology understanding and regulatory expectations for pharmacometrics analyses
- Ability to interpret quantitative results and translate them into actionable program insights
- Hands-on experience with NONMEM, Monolix, and R
Preferred
- Experience with mechanistic or systems pharmacology models