Associate Principal Scientist, Translational PKPD Modeling & DMPK (Oncology)
AstraZeneca
Full-time
Remote friendly (Waltham, MA)
United States
Clinical Research and Development
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Role Summary
Associate Principal Scientist, Translational PKPD Modeling & DMPK (Oncology). Focus on PKPD modeling and DMPK science applied to Cancer biology, with experience in biologics drug projects and translational PKPD strategies to inform dose/schedule in preclinical and early clinical settings.
Responsibilities
- Represent Oncology DMPK, providing scientific leadership in cross-functional and external collaborations.
- Develop and apply PKPD models to explore target and pathway modulation, defining candidate drug target profiles.
- Predict human dose and regimen, contributing to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials.
- Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing.
- Lead and participate in strategic scientific initiatives, continuous improvement projects, and external collaborations with academic or pre-competitive groups.
- Mentor students and postdoctoral fellows, contributing to the next generation of scientific talent.
- Present findings through publications, patents, and lectures, enhancing the visibility of translational research.
Qualifications
- Ph.D. in Modeling & Simulation, systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences, or applied mathematics.
- 5 years of relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on biologics, or an MS degree with 8 years of proven industry experience.
- Experience in a project-facing role within pharmaceutical R&D.
- Strong understanding of DMPK and pharmacology in drug discovery, with a track record of delivering results in a fast-paced environment.
- Proficiency with tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.
- Excellent interpersonal, communication, and leadership skills, with a passion for collaborative problem-solving.
Skills
- PKPD modeling and translational pharmacology
- Biologics drug project experience
- Cross-functional collaboration and leadership
- Computational tools: WinNonLin, Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, SimCYP