Associate Principal Scientist, Materials and Biophysical Characterization AR&D

Role Summary

The Materials and Biophysical Characterization group is responsible for physical and biophysical characterization across our development pipeline, including small molecules, biologics, and vaccines. We seek a highly self-motivated scientist with experience in biotherapeutics and materials characterization. As an Associate Principal Scientist, you will lead the physical characterization of biotherapeutics focusing on protein higher-order structure and particles, and collaborate with cross-functional teams to support the pipeline from discovery through development to launch. You will contribute to interdepartmental initiatives, build internal and external networks, and foster a culture of scientific excellence and compliance.

Responsibilities

• Lead physical characterization of biotherapeutics, focusing on protein higher-order structure and particles.
• Collaborate with development scientists to deeply understand products and processes.
• Participate on cross-functional technical teams and contribute to interdepartmental initiatives.
• Support the pipeline from discovery through development to commercial launch.
• Build a strong internal and external network across academia and regulatory communities.
• Contribute to a culture of scientific excellence and a compliance mindset.
• Collaborate with partners and stakeholders across the company to impact the pipeline and patient lives.

Qualifications

• Required: Strong background in biophysical/biochemistry/physical chemistry/material sciences
• Required: Self-motivated with an outstanding scientific track-record.
• Required: Excellent interpersonal and communication skills, both verbal and written.
• Required: Track-record of independent problem-solving and application of advanced innovative scientific approaches.
• Required: Desire and willingness to learn, contribute and mentor junior scientists in the group.
• Required: Excellent organizational skills to multi-task and manage multiple projects.
• Preferred: Experience with biophysical and biochemical techniques for biotherapeutics characterization.
• Preferred: In-depth understanding of protein science, protein stability, and protein-protein interactions
• Preferred: Rheological characterization of complex fluids or suspensions
• Preferred: Experience with solid-state and solution characterization of small and large molecules
• Preferred: Experience with formulation development and analytical method development.
• Preferred: Experience with various modalities including mAbs, ADC, cytokine, fusion proteins, gene therapy, engineered cellular therapies

Skills

• Accountability
• Adaptability
• Analytical Method Development
• Assay Development
• Biological Assay Development
• Biomedical Engineering
• Cell-Based Assays
• Chemical Engineering
• Chemical Physics
• Chromatographic Techniques
• Communication
• Cross-Functional Teamwork
• Cytokines
• External Collaboration
• Gene Therapy
• High Resolution Mass Spectrometry (HRMS)
• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Mass Spectrometry Analysis
• Materials Characterization
• Materials Science
• Optimistic Attitude
• Pharmaceutical Sciences
• Pharmacology
• Process Analytical Technology (PAT)

Education

• Masters in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Material Sciences, Biomedical Engineering, Pharmaceutical Sciences or related discipline with a minimum of 8 years relevant industrial experience.
• Ph.D. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Material Sciences, Biomedical Engineering, Pharmaceutical Sciences or related discipline with a minimum of 4 years of relevant experience.

Additional Requirements

• Travel: 10%