Associate Principal Scientist, In Vivo Pharmacology, Oncology
Merck
August 24, 2026
On-site
Boston, MA
Clinical Research and Development
Associate Principal Scientist – Oncology In Vivo Pharmacology
Responsibilities:
- Perform preclinical experiments to support discovery and clinical development of novel Oncology compounds.
- Manage external studies at CROs and academic collaborators; monitor execution and ensure timely completion of study reports.
- Partner with global/network objectives to stay at the forefront of drug discovery.
- Drive innovation and continuous improvement in QB/Pharmacology by developing and adopting new methodologies/technologies.
- Ensure compliance with established practices and procedures, including lab notebooks, quality/regulatory guidelines, and safety standards.
Education:
- PhD in Oncology/Pharmacology/Biology/related STEM with 5+ years industry/biotech Oncology drug discovery experience; or MS with 7+ years; or BS with 10+ years.
Required Skills:
- Use preclinical models to evaluate in vivo pharmacology of modality-agnostic oncology drugs (small molecules, antibodies, ADCs, etc.).
- Manage external CRO/academic studies with timely, high-quality reporting.
- Proven managerial/supervisory experience: training, developing, mentoring.
- Strong problem-solving; ability to influence strategy across organizational boundaries.
- Strategic thinking, communication, collaboration, balanced risk-taking, pursuit of excellence.
Required/Relevant Technical Skills:
- Immunoassays, IHC, Immunology, In vivo models/studies, mass spectrometry imaging, molecular biology, mouse models, multiplex assays, pharmacodynamics/pharmacokinetics, preclinical research, tumor biology.
Application:
- Apply via https://jobs.merck.com/us/en.
Responsibilities:
- Perform preclinical experiments to support discovery and clinical development of novel Oncology compounds.
- Manage external studies at CROs and academic collaborators; monitor execution and ensure timely completion of study reports.
- Partner with global/network objectives to stay at the forefront of drug discovery.
- Drive innovation and continuous improvement in QB/Pharmacology by developing and adopting new methodologies/technologies.
- Ensure compliance with established practices and procedures, including lab notebooks, quality/regulatory guidelines, and safety standards.
Education:
- PhD in Oncology/Pharmacology/Biology/related STEM with 5+ years industry/biotech Oncology drug discovery experience; or MS with 7+ years; or BS with 10+ years.
Required Skills:
- Use preclinical models to evaluate in vivo pharmacology of modality-agnostic oncology drugs (small molecules, antibodies, ADCs, etc.).
- Manage external CRO/academic studies with timely, high-quality reporting.
- Proven managerial/supervisory experience: training, developing, mentoring.
- Strong problem-solving; ability to influence strategy across organizational boundaries.
- Strategic thinking, communication, collaboration, balanced risk-taking, pursuit of excellence.
Required/Relevant Technical Skills:
- Immunoassays, IHC, Immunology, In vivo models/studies, mass spectrometry imaging, molecular biology, mouse models, multiplex assays, pharmacodynamics/pharmacokinetics, preclinical research, tumor biology.
Application:
- Apply via https://jobs.merck.com/us/en.