Associate Principal Scientist, In Vivo Pharmacology
Merck
13 days ago
On-site
South San Francisco, CA
Clinical Research and Development
Key Responsibilities
- Drive in vivo pharmacology strategy: lead in vivo model development and pharmacology strategy for preclinical programs; design and execute target engagement, PD, and efficacy studies; troubleshoot complex surgical and study protocols.
- Leverage disease area expertise (cardiometabolic, renal, respiratory) to guide model selection/prioritization.
- Lead model development & validation for target validation, compound screening/characterization, and mechanism-of-action studies.
- Collaborate cross-functionally (Biology, Med Chem, DMPK, Safety, etc.) to enable pharmacology strategy including target engagement, in vitro/in vivo correlation, PK/PD, and human dose projection.
- Data analysis, interpretation, and reporting: analyze data, translate findings into actionable insights; maintain experimental documentation and contribute to internal reports and regulatory submissions/publications.
- Manage CROs and external partners to design/execute studies ensuring data quality and timely delivery.
Qualifications
- Education: BS (12+ years), MS (8+ years), or PhD/PharmD/DVM/MD (4+ years) in Pharmacology or relevant discipline with drug discovery experience.
Required Experience and Skills
- Quantitative/translational pharmacology expertise: target occupancy, in vitro/in vivo correlation, PK/PD, translational biomarkers, human dose projection.
- Proven preclinical in vivo model development; strong cardiovascular physiology and rodent surgical skills for disease models.
- Expertise designing/executing animal studies for target engagement, PK/PD, efficacy, and safety using in vivo and ex vivo techniques.
- Exceptional organization and detail; manage complex preclinical projects; strong teamwork/communication in cross-functional settings.
- Onsite 5 days/week; flexible, able to respond to shifting priorities.
Preferred
- In vivo imaging (ultrasound, MRI, optical imaging, etc.).
- Experience with multiple therapeutic modalities (small molecule, peptide, biologic, etc.).
Benefits/Compensation
- Annual bonus and long-term incentive, if applicable.
- Comprehensive benefits including medical/dental/vision, retirement (401(k)), paid holidays, vacation, and sick/compassionate days.
Application
- Apply via https://jobs.merck.com/us/en (deadline stated on posting). Requisition ID: R397083.
- Drive in vivo pharmacology strategy: lead in vivo model development and pharmacology strategy for preclinical programs; design and execute target engagement, PD, and efficacy studies; troubleshoot complex surgical and study protocols.
- Leverage disease area expertise (cardiometabolic, renal, respiratory) to guide model selection/prioritization.
- Lead model development & validation for target validation, compound screening/characterization, and mechanism-of-action studies.
- Collaborate cross-functionally (Biology, Med Chem, DMPK, Safety, etc.) to enable pharmacology strategy including target engagement, in vitro/in vivo correlation, PK/PD, and human dose projection.
- Data analysis, interpretation, and reporting: analyze data, translate findings into actionable insights; maintain experimental documentation and contribute to internal reports and regulatory submissions/publications.
- Manage CROs and external partners to design/execute studies ensuring data quality and timely delivery.
Qualifications
- Education: BS (12+ years), MS (8+ years), or PhD/PharmD/DVM/MD (4+ years) in Pharmacology or relevant discipline with drug discovery experience.
Required Experience and Skills
- Quantitative/translational pharmacology expertise: target occupancy, in vitro/in vivo correlation, PK/PD, translational biomarkers, human dose projection.
- Proven preclinical in vivo model development; strong cardiovascular physiology and rodent surgical skills for disease models.
- Expertise designing/executing animal studies for target engagement, PK/PD, efficacy, and safety using in vivo and ex vivo techniques.
- Exceptional organization and detail; manage complex preclinical projects; strong teamwork/communication in cross-functional settings.
- Onsite 5 days/week; flexible, able to respond to shifting priorities.
Preferred
- In vivo imaging (ultrasound, MRI, optical imaging, etc.).
- Experience with multiple therapeutic modalities (small molecule, peptide, biologic, etc.).
Benefits/Compensation
- Annual bonus and long-term incentive, if applicable.
- Comprehensive benefits including medical/dental/vision, retirement (401(k)), paid holidays, vacation, and sick/compassionate days.
Application
- Apply via https://jobs.merck.com/us/en (deadline stated on posting). Requisition ID: R397083.