Associate Principal Scientist, In Vivo Pharmacology

Role: Associate Principal Scientist in In Vivo Pharmacology focused on cardiometabolic, renal, and respiratory diseases. Primary objectives include developing and executing in vivo pharmacology strategies, models, and assays to support preclinical drug programs. Responsibilities encompass designing target engagement, PD, and efficacy studies; developing validated animal models; analyzing and interpreting complex data; and collaborating with multidisciplinary teams and external partners. Qualifications: PhD/PharmD/DVM/MD or MS with 4+ to 12+ years in pharmacology or drug discovery, with expertise in translational pharmacology, PK/PD, target occupancy, and disease-specific animal models. Strong leadership, communication, and project management skills are essential. Preferred experience includes in vivo imaging techniques, cross-modality work, and being a pharmacology lead on project teams. High-value biopharma specifics include focus on cardiometabolic, renal, and respiratory disorders, with emphasis on quantitative pharmacology, model/assay development, and multidisciplinary collaboration. The role requires onsite presence in South San Francisco with approximately 10% travel, supporting cross-functional activities in early to late preclinical development stages.