Associate Principal Scientist, Gene Editing and Biologics Research

Role Summary

Associate Principal Scientist, Gene Editing and Biologics Research – lead discovery and development campaigns focused on next-generation biotherapies and gene editing technologies within a multidisciplinary team.

Responsibilities

• Drive biomolecular engineering and pharmacology efforts within research projects, including strategy and methods development
• Mentor and develop a team of project scientists focused on protein engineering and next-generation gene editing technologies
• Conceptualize, construct, validate, and implement high throughput screening platforms for candidate selection from large panels and combinatorial libraries of engineered protein variants
• Develop, validate, and deploy functional and pharmacological assays to characterize protein performance in vitro and in vivo
• Establish and manage partnerships with research teams from computational biology, immunology, bioanalytical, in vivo, and formulation science
• Collaborate with cross-functional teams from DMPK, toxicology, translational bioanalytics, technical operations, and program management
• Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis in electronic notebooks and technical reports
• Perform data review to ensure accuracy, completeness, and validity
• Present scientific results to the larger research group and external scientific community as needed
• Assist with coordination and day-to-day management of site operations

Qualifications

• Requires a minimum of a PhD and 9+ years of experience in molecular and cellular biology, bioengineering, biochemistry, immunology, microbiology, or related field
• Demonstrated management and leadership experience
• Deep expertise in therapeutic gene editing
• Mastery of applied molecular and cellular biology, protein biochemistry, recombinant DNA technology, protein mutagenesis, and high throughput library screening
• Experience with translational in vivo models of genetic disease and therapeutic gene therapy/editing
• Excellent verbal and written communication and problem-solving skills
• Highly organized with attention to detail, clarity, accuracy, and conciseness