Associate Principal Scientist, Gene Editing and Biologics Research
Insmed Incorporated
Full-time
Remote friendly (Joint Training and Training Development Center, NJ)
United States
$127,000 - $178,533 USD yearly
Clinical Research and Development
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Role Summary
Associate Principal Scientist, Gene Editing and Biologics Research – lead discovery and development campaigns focused on next-generation biotherapies and gene editing technologies within a multidisciplinary team.
Responsibilities
- Drive biomolecular engineering and pharmacology efforts within research projects, including strategy and methods development
- Mentor and develop a team of project scientists focused on protein engineering and next-generation gene editing technologies
- Conceptualize, construct, validate, and implement high throughput screening platforms for candidate selection from large panels and combinatorial libraries of engineered protein variants
- Develop, validate, and deploy functional and pharmacological assays to characterize protein performance in vitro and in vivo
- Establish and manage partnerships with research teams from computational biology, immunology, bioanalytical, in vivo, and formulation science
- Collaborate with cross-functional teams from DMPK, toxicology, translational bioanalytics, technical operations, and program management
- Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis in electronic notebooks and technical reports
- Perform data review to ensure accuracy, completeness, and validity
- Present scientific results to the larger research group and external scientific community as needed
- Assist with coordination and day-to-day management of site operations
Qualifications
- Requires a minimum of a PhD and 9+ years of experience in molecular and cellular biology, bioengineering, biochemistry, immunology, microbiology, or related field
- Demonstrated management and leadership experience
- Deep expertise in therapeutic gene editing
- Mastery of applied molecular and cellular biology, protein biochemistry, recombinant DNA technology, protein mutagenesis, and high throughput library screening
- Experience with translational in vivo models of genetic disease and therapeutic gene therapy/editing
- Excellent verbal and written communication and problem-solving skills
- Highly organized with attention to detail, clarity, accuracy, and conciseness