Associate Manager, Statistical Genetics

Company Name

Regeneron

Job Description

We are looking for a statistical geneticist to contribute to the analysis and interpretation of millions of genotyped and sequenced humans linked with rich phenotype data from around the world. You will leverage these data to gain new insights into disease mechanisms and generate new discoveries that enable Regeneron to create and deliver better medicines to patients in need. Within the broad domain of cardiovascular, metabolic disease, and skeletal diseases, you will work collaboratively with other specialists in genomic data analysis, translational genetics, functional biology, and medicine, to design, execute, and refine analyses that connect genetic variation to human health and disease. You will help develop and implement statistical and computational tools that will allow these analyses to be executed and interpreted at scale.

A Typical Day Might Include The Following

• Perform genome scale analyses with genotype, imputed, and sequence data from millions of individuals across hundreds of relevant phenotypes and biomarkers.
• Work across teams to maintain and improve analytical workflows and implement analytical best practices.
• Integrate computational tools and diverse molecular data types to generate insights about human disease, interpret results, and prioritize candidate therapeutic targets.
• Critically review and provide input on analysis plans, results, and summaries to ensure accuracy and reliability. Identify problems and propose solutions or analytical refinements.

This Role Might Be For You If You

• Have experience in the analysis of large genetic association studies and meta-analysis, including through the analysis of UK Biobank or other biobank-scale data.
• Have experience in the management of genetic and phenotype data in human genetic studies, including familiarity manipulating sequence data (e.g., VCF files), strategies for genotype imputation, and for quality control of genetic association inputs and outputs.
• Have demonstrated coding ability in either Python, C/C++, or R.
• Enjoy working in a highly interactive environment with a diverse team of colleagues.
• Employ outstanding communication skills to summarize and present new concepts, methods, and results from human genetic studies to a variety of audiences.

To be considered for this role

You must have a PhD in Human Genetics, Biostatistics, or a related field with a minimum of 0-2 years of experience, postdoctoral training or relevant industry experience is preferred. The successful candidate should have experience and competence with approaches currently employed in the group, including genome- and exome-wide association analysis, rare variant analysis, Mendelian randomization, LD Score regression, polygenic risk score modelling, meta-analysis, and the use of functional data to prioritize variants and genes of interest. Expertise with cloud computing environments, advanced tools for genomic analyses (PLINK, REGENIE, etc.), and statistical analysis and computation (R, Python, C/C++) are necessary. Experience working in cardiovascular, metabolic, and/or musculoskeletal disease is preferred.

Does this sound like you?

Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Equal Opportunity Employer

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

Salary Information

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S., Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications, etc.

Salary Range (annually)

$108,300.00 - $176,700.00