Associate Director, Translational Toxicology, Preclinical Development

Role: Lead safety assessment for novel oligonucleotide therapeutics targeting rare diseases, supporting the discovery and development pipeline. Responsibilities: design and oversee GLP-compliant toxicology studies, evaluate safety data, collaborate with cross-functional teams including CMC, Regulatory, Clinical, and Platform Sciences, and provide strategic risk assessments. Lead early mechanism-of-toxicity investigations and communicate findings to teams and regulatory bodies. Requirements: PhD or DVM in biology, toxicology, or related field; 7+ years in preclinical safety assessment of therapeutic agents; experience with regulatory submissions and GLP toxicology studies; board certification in toxicology preferred. High-Value: expertise in safety pharmacology, investigational and regulatory toxicology, and nonclinical document authoring; background in hepatic, renal, muscular, or CNS disease models; experience with RNA-based modalities and rare disease programs; familiarity with ICH and FDA guidance. Collaboration: represent Preclinical Development Sciences on Program Teams and coordinate with external CROs; interface with multiple disciplines to support candidate progression. Work Setup: location in Lexington, Massachusetts; no specific travel requirements stated.