Associate Director, Translational Modeling & Simulation
Novartis
August 29, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Key responsibilities:
- Serve as the M&S representative on multiple programs; develop and execute modeling strategies and guide model-informed decisions from therapeutic design through first-in-human dose selection.
- Build and apply mechanistic models (PK/PD, QSP, PBPK/PD) linking drug pharmacology, tissue biodistribution, mechanisms of action, and downstream effects.
- Integrate modeling into preclinical in vivo/in vitro study design and interpretation to support candidate selection, optimization, and advancement to clinic.
- Collaboratively develop platform disease (QSP) and PBPK/PD models spanning multiple projects and development phases.
- Lead/participate in M&S strategic initiatives (e.g., platform-level translational modeling strategies and new modeling workflows such as agentic AI).
- Promote adoption of translational modeling internally and expand impact via external collaborations.
- Provide additional mentorship and strategic responsibilities at the Associate Director level within M&S.
Essential requirements:
- Ph.D. in biology, bioengineering, pharmaceutical sciences, biophysics, or related field and 7+ years of industry experience with increasing responsibility.
- Expert modeling skills: MATLAB/R scripting, ODE model construction, parameter estimation, data visualization.
- Expert knowledge of PK/PD, QSP, and/or mechanistic PBPK/PD; pharmacometrics concepts (Population PK, exposure-response modeling) preferred.
- Prior experience integrating computational modeling with biological concepts; neuroscience/cardiovascular/metabolism and oligonucleotides/ADCs preferred but not required.
- Ability to communicate modeling results to multidisciplinary teams; fluent English (oral/written).
- Serve as the M&S representative on multiple programs; develop and execute modeling strategies and guide model-informed decisions from therapeutic design through first-in-human dose selection.
- Build and apply mechanistic models (PK/PD, QSP, PBPK/PD) linking drug pharmacology, tissue biodistribution, mechanisms of action, and downstream effects.
- Integrate modeling into preclinical in vivo/in vitro study design and interpretation to support candidate selection, optimization, and advancement to clinic.
- Collaboratively develop platform disease (QSP) and PBPK/PD models spanning multiple projects and development phases.
- Lead/participate in M&S strategic initiatives (e.g., platform-level translational modeling strategies and new modeling workflows such as agentic AI).
- Promote adoption of translational modeling internally and expand impact via external collaborations.
- Provide additional mentorship and strategic responsibilities at the Associate Director level within M&S.
Essential requirements:
- Ph.D. in biology, bioengineering, pharmaceutical sciences, biophysics, or related field and 7+ years of industry experience with increasing responsibility.
- Expert modeling skills: MATLAB/R scripting, ODE model construction, parameter estimation, data visualization.
- Expert knowledge of PK/PD, QSP, and/or mechanistic PBPK/PD; pharmacometrics concepts (Population PK, exposure-response modeling) preferred.
- Prior experience integrating computational modeling with biological concepts; neuroscience/cardiovascular/metabolism and oligonucleotides/ADCs preferred but not required.
- Ability to communicate modeling results to multidisciplinary teams; fluent English (oral/written).