Associate Director, Toxicology
Denali Therapeutics
19 days ago
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Key Accountabilities / Core Job Responsibilities:
- Develop and lead nonclinical toxicology strategies for multiple programs across discovery and development stages
- Interpret toxicology and safety pharmacology data to inform risk assessment and program decisions
- Provide strategic input into regulatory submissions, including IND-enabling studies and health authority interactions
- Influence cross-functional teams by integrating toxicology insights with clinical, regulatory, and translational considerations
- Oversee design, execution, and interpretation of outsourced and internal toxicology studies
- Identify and mitigate safety risks, proposing alternative strategies to advance programs
- Contribute to governance discussions, representing toxicology perspectives in decision-making forums
- Build external scientific network and monitor emerging trends in toxicology and safety sciences
- Mentor junior scientists and provide scientific guidance across the organization
- Drive continuous improvement of toxicology processes, tools, and scientific approaches
Qualifications / Skills:
- Typically PhD in Toxicology, Pharmacology, or related life sciences with 10+ years of relevant industry experience (or equivalent education/experience)
- Demonstrated expertise in nonclinical safety assessment across multiple therapeutic modalities or indications
- Proven ability to lead toxicology strategy for programs advancing into clinical development
- Experience supporting regulatory submissions and interacting with health authorities preferred
- Strong scientific judgment; ability to interpret complex and ambiguous data sets
- Ability to influence cross-functional teams without direct authority
- Effective communication skills, translating technical findings into business and clinical implications
Compensation / Benefits:
- Salary range: $171,000–$223,000; includes 401k, healthcare coverage, ESPP, and other benefits
Application Instructions:
- Learn more at https://www.denalitherapeutics.com/careers
- Develop and lead nonclinical toxicology strategies for multiple programs across discovery and development stages
- Interpret toxicology and safety pharmacology data to inform risk assessment and program decisions
- Provide strategic input into regulatory submissions, including IND-enabling studies and health authority interactions
- Influence cross-functional teams by integrating toxicology insights with clinical, regulatory, and translational considerations
- Oversee design, execution, and interpretation of outsourced and internal toxicology studies
- Identify and mitigate safety risks, proposing alternative strategies to advance programs
- Contribute to governance discussions, representing toxicology perspectives in decision-making forums
- Build external scientific network and monitor emerging trends in toxicology and safety sciences
- Mentor junior scientists and provide scientific guidance across the organization
- Drive continuous improvement of toxicology processes, tools, and scientific approaches
Qualifications / Skills:
- Typically PhD in Toxicology, Pharmacology, or related life sciences with 10+ years of relevant industry experience (or equivalent education/experience)
- Demonstrated expertise in nonclinical safety assessment across multiple therapeutic modalities or indications
- Proven ability to lead toxicology strategy for programs advancing into clinical development
- Experience supporting regulatory submissions and interacting with health authorities preferred
- Strong scientific judgment; ability to interpret complex and ambiguous data sets
- Ability to influence cross-functional teams without direct authority
- Effective communication skills, translating technical findings into business and clinical implications
Compensation / Benefits:
- Salary range: $171,000–$223,000; includes 401k, healthcare coverage, ESPP, and other benefits
Application Instructions:
- Learn more at https://www.denalitherapeutics.com/careers