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Associate Director Scientist – Biomeasures

Amgen
Full-time
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development

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Role Summary

Associate Director Scientist

Let’s do this. Let’s change the world. In this vital role you will be instrumental in advancing our pipeline by driving novel strategies to characterize drug–target interactions, leveraging microphysiological models to better predict clinical outcomes, and developing next level analytical techniques to describe the system.

Responsibilities

  • Scientific Leadership
  • Lead strategic initiatives focused on understanding drug‚Äìtarget engagement, binding kinetics, and pharmacodynamics across multiple therapeutic areas.
  • Design and execute innovative studies using advanced microphysiological systems (e.g., organ-on-chip, 3D cell culture, bioreactor-based systems) to model human disease and drug response.
  • Provide scientific and technical insight to describe the abundance, dynamics, engagement, and fate of drug targets.
  • Provide analytical technical leadership across a range of platforms to address target.
  • Cross-Functional Representation
  • Provide guidance and scientific interpretation to project teams related to biomeasures.
  • Translate complex scientific findings into clear, actionable strategies for non-scientific stakeholders, including senior leadership.
  • Act as a thought leader and external representative by contributing to publications, presentations, and collaborations with academic and industry partners.
  • Innovation & Strategy
  • Identify and champion opportunities for emerging technologies that advance drug‚Äìtarget understanding and improve translational success rates.
  • Advance the use of MPS technologies for better understanding of target biology.
  • Contribute to long-term research strategy development, including evaluation of new therapeutic modalities and platforms.
  • Mentorship & Team Development
  • Provide scientific mentorship to junior scientists, fostering an environment of innovation, collaboration, and continuous learning.
  • Promote a culture of rigorous science, open communication, and cross-disciplinary teamwork.

Qualifications

  • Basic Qualifications:
    • Doctorate degree (PhD OR PharmD OR MD) and 4 years of Pharmacology, Biophysics, Systems Biology, Biomedical Engineering, or a related field.
    • Or Master‚Äôs degree and 7 years of Pharmacology, Biophysics, Systems Biology, Biomedical Engineering, or a related field.
    • Or Bachelor‚Äôs degree and 9 years of Pharmacology, Biophysics, Systems Biology, Biomedical Engineering, or a related field.
  • Preferred Qualifications:
    • Minimum of 8‚Äì10 years of experience in drug discovery and translational research, with at least 3‚Äì5 years in a leadership role.
    • Proven expertise in drug‚Äìtarget dynamics (binding kinetics, occupancy, target engagement assays).
    • Strong track record in developing and applying microphysiological systems for preclinical studies.
    • Experience working in matrixed, cross-functional project teams within biopharma or biotech.
    • Skills:
      • Exceptional communication skills with the ability to represent projects at senior levels and external forums.
      • Demonstrated ability to integrate complex datasets into coherent translational strategies.
      • Strong leadership and mentoring capabilities
      • Publications and conference presentations in the areas of drug‚Äìtarget dynamics or bioanalysis.
      • Established network within the academic and industry research community.

Skills

  • Communication
  • Strategy development
  • Leadership and mentorship
  • Data integration and translational science
  • External collaboration and publication

Education

  • Doctorate degree (PhD, PharmD, or MD) or Master‚Äôs/Bachelor‚Äôs with relevant experience as listed in Basic Qualifications
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