Associate Director, Quantitative Systems Pharmacology

Role: Associate Director of Quantitative Systems Pharmacology (QSP) supporting RNAi therapeutics in a fast-growing clinical pipeline. Objectives include applying QSP modeling to inform dose selection, trial design, and understanding disease mechanisms across all development stages. Responsibilities involve strategizing, executing, and interpreting QSP models, collaborating closely with clinical pharmacologists, pharmacometricians, and research teams to integrate preclinical and clinical data, and advancing modeling methodologies. The role entails building biological process models, analyzing results for internal decision-making, and promoting scientific visibility through publications and presentations. Qualifications: Ph.D. or equivalent in applied mathematics, systems biology, pharmacology, or related fields; minimum 5 years’ industry, consulting, or regulatory experience with a proven impact of QSP modeling on drug development. Skills include strong knowledge of systems biology, pharmacokinetics, pharmacodynamics, differential equation-based modeling, and proficiency with platforms like R, MATLAB, or Simbiology. High-value specifics: focus on RNAi therapeutics, early to late-stage development, cross-functional collaboration in a highly matrixed environment, and expert communication skills. The role may be remote or hybrid, with no specific travel requirements noted.