Associate Director, Quantitative System Pharmacology (QSP)

Role: Associate Director, Quantitative System Pharmacology (QSP), contributing to Model-informed Drug Development (MIDD) strategies across preclinical, translational, and clinical phases for autoimmune and inflammation biologics. Responsibilities: develop and execute fit-for-purpose QSP and (m)PBPK models, support simulation efforts, collaborate with cross-functional teams (biology, chemistry, pharmacology), and communicate modeling insights to accelerate program progression. Qualifications: PhD with 6+ years in QSP, (m)PBPK, or related fields, with hands-on proficiency in MATLAB/Simbiology, R, GastroPlus, or similar software. Experience with therapeutic antibodies and biologics is essential, with demonstrated success in preclinical, translational, and clinical pharmacology. High-value specifics: focus on autoimmune/inflammation indications, biologics modalities, and mechanistic modeling support. Work setup: hybrid in Waltham, MA, or remote with travel to headquarters as needed. The role requires strong communication skills, proactive mindset, attention to detail, and ability to work in a fast-paced environment.