Associate Director, Quantitative Clinical Pharmacology
Sarepta Therapeutics
June 27, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
The Associate Director, Quantitative Clinical Pharmacology provides translational, clinical pharmacology, and pharmacometrics deliverables for development assets from pre-IND to Phase III. Applies quantitative modeling methodologies including population PK, PK/PD, and disease progression modeling (multivariate statistical and empirical approaches) to integrate, analyze, and interpret diverse data sources (pharmacokinetics, pharmacodynamics including biomarker/imaging, and electronic health records). Drives and supports pharmacology and pharmacometrics activities for dose selection and characterizing interactions between drugs, patients, and biological systems to identify key predictors (highly visible, team-facing).
Responsibilities:
- Develop and execute quantitative pharmacology strategies across development through product registration.
- Lead clinical pharmacology expertise for clinical/translational development (protocol preparation, study execution, data review/analysis, study reports).
- Perform advanced quantitative pharmacology and pharmacometrics analyses (population PK, PK/PD modeling and simulation, meta-analysis, disease modeling) to support clinical decisions and dose selection.
- Serve as functional lead for global regulatory strategies and regulatory documents.
- Maintain and share leading-edge knowledge (manuscripts, scientific conferences/forums).
Qualifications:
- PhD in Pharmaceutical Sciences, mathematics/engineering, or related field; minimum 5 years in clinical pharmacology or pharmacometrics.
- Strong clinical pharmacology principles; hands-on PK/PD modeling; experience with regulatory interactions.
- Experience developing pharmacometrics/PK/PD/PBPK models; skilled with NONMEM, R, or Phoenix.
- Excellent communication, multitasking, collaboration; strong analytical and strategic thinking.
Application instructions:
- Encourage to apply if solution-oriented, comfortable with ambiguity/candor, and values kindness and integrity.
Benefits:
- Physical and Emotional Wellness; Financial Wellness; Support for Caregivers.
Hybrid/on-site:
- Hybrid; expected to work on site in the U.S. and/or attend in-person events.
Salary range:
- $160,800 - $201,000 per year.
Responsibilities:
- Develop and execute quantitative pharmacology strategies across development through product registration.
- Lead clinical pharmacology expertise for clinical/translational development (protocol preparation, study execution, data review/analysis, study reports).
- Perform advanced quantitative pharmacology and pharmacometrics analyses (population PK, PK/PD modeling and simulation, meta-analysis, disease modeling) to support clinical decisions and dose selection.
- Serve as functional lead for global regulatory strategies and regulatory documents.
- Maintain and share leading-edge knowledge (manuscripts, scientific conferences/forums).
Qualifications:
- PhD in Pharmaceutical Sciences, mathematics/engineering, or related field; minimum 5 years in clinical pharmacology or pharmacometrics.
- Strong clinical pharmacology principles; hands-on PK/PD modeling; experience with regulatory interactions.
- Experience developing pharmacometrics/PK/PD/PBPK models; skilled with NONMEM, R, or Phoenix.
- Excellent communication, multitasking, collaboration; strong analytical and strategic thinking.
Application instructions:
- Encourage to apply if solution-oriented, comfortable with ambiguity/candor, and values kindness and integrity.
Benefits:
- Physical and Emotional Wellness; Financial Wellness; Support for Caregivers.
Hybrid/on-site:
- Hybrid; expected to work on site in the U.S. and/or attend in-person events.
Salary range:
- $160,800 - $201,000 per year.