Associate Director - QSP Quantitative Systems Pharmacology
Sanofi
August 24, 2026
On-site
Morristown, NJ
$148,500 - $247,500 USD yearly
Clinical Research and Development
Position Objectives
- Design, build, and apply QSP modeling approaches to support decision making within the neurology therapeutic area.
Main Responsibilities
- Interface with project teams to align modeling & simulation needs and develop QSP strategy.
- Develop and implement innovative mechanistic modeling strategies to support project team M&S needs.
- Communicate modeling predictions to key stakeholders to inform strategy and decision-making.
- Identify and interpret preclinical and clinical data critical for model development and refinement.
- Stay current with advances in systems pharmacology, disease modeling, and regulatory expectations for model-informed drug development.
- Contribute to abstracts and manuscripts.
- Perform job duties independently with minimal supervision and mentor others.
Qualifications
- Ph.D. in Biomedical Engineering, Applied Mathematics, Systems Biology/Pharmacology, or related field.
- 6+ years of hands-on QSP modeling experience in pharma/biotech with impact on R&D programs.
- Demonstrated independence leading scientific projects; strong publication record in QSP modeling.
- Hands-on programming experience with Matlab/R/Julia (Matlab preferred).
- Experience using QSP models to influence go/no-go decisions.
- Deep understanding of disease biology in at least one therapeutic area; apply QSP across multiple programs or drug modalities.
- Experience with heterogeneous datasets (preclinical and clinical).
- Experience with reproducible, well-documented modeling workflows.
- Ability to lead modeling workstreams and communicate insights to scientific and non-scientific stakeholders.
- Experience mentoring junior scientists.
Knowledge and Skills Desirable (Not Essential)
- Understanding of neurology, neuroinflammation, and neurodegeneration.
- Exposure to regulatory interactions/documentation involving modeling and simulation.
- Design, build, and apply QSP modeling approaches to support decision making within the neurology therapeutic area.
Main Responsibilities
- Interface with project teams to align modeling & simulation needs and develop QSP strategy.
- Develop and implement innovative mechanistic modeling strategies to support project team M&S needs.
- Communicate modeling predictions to key stakeholders to inform strategy and decision-making.
- Identify and interpret preclinical and clinical data critical for model development and refinement.
- Stay current with advances in systems pharmacology, disease modeling, and regulatory expectations for model-informed drug development.
- Contribute to abstracts and manuscripts.
- Perform job duties independently with minimal supervision and mentor others.
Qualifications
- Ph.D. in Biomedical Engineering, Applied Mathematics, Systems Biology/Pharmacology, or related field.
- 6+ years of hands-on QSP modeling experience in pharma/biotech with impact on R&D programs.
- Demonstrated independence leading scientific projects; strong publication record in QSP modeling.
- Hands-on programming experience with Matlab/R/Julia (Matlab preferred).
- Experience using QSP models to influence go/no-go decisions.
- Deep understanding of disease biology in at least one therapeutic area; apply QSP across multiple programs or drug modalities.
- Experience with heterogeneous datasets (preclinical and clinical).
- Experience with reproducible, well-documented modeling workflows.
- Ability to lead modeling workstreams and communicate insights to scientific and non-scientific stakeholders.
- Experience mentoring junior scientists.
Knowledge and Skills Desirable (Not Essential)
- Understanding of neurology, neuroinflammation, and neurodegeneration.
- Exposure to regulatory interactions/documentation involving modeling and simulation.