Associate Director Preclinical & Translational PK/PD
Regeneron
August 06, 2026
On-site
Tarrytown, NY
Clinical Research and Development
Associate Director of Translational/Preclinical Modeling: Develop and implement quantitative and mechanistic PK/PD models to support target biology understanding, therapeutic modality selection/optimization, and early clinical trial dose selection/design and strategic direction of modeling and simulation sciences.
A Typical Day May Include:
- Independently develop and implement quantitative and mechanistic mathematical PK/PD models for preclinical-to-early clinical translation (human efficacious dose predictions and first-in-human dose selection).
- Advance and shape the strategic direction of modeling and simulation sciences.
- Provide expert support to pre-clinical PK/PD project representatives and R&D teams to design, execute, and interpret in vitro/in vivo quantitative pharmacology studies, including optimizing mouse PK data for translation to nonhuman primate and human PK.
- Integrate and summarize modeling and simulation analyses for multidisciplinary teams.
- Stay current on emerging science and literature; collaborate with Clinical Pharmacology, Quantitative Pharmacology, and R&D experts.
- Present at scientific meetings and publish in scientific journals.
This Role Might Be For You If:
- Experience with modeling/simulation platforms (e.g., Phoenix NLME, NONMEN, Monolix, ADAPT, MATLAB, SimBiology).
- Strong PK foundation: non-compartmental, compartmental, PK/PD, PBPK.
- Ability to work effectively in fast-paced, matrixed environments.
- Ability to learn biological sciences for emerging therapeutic modalities.
- Familiarity with biotherapeutic modalities (monoclonal/bispecific antibodies, gene therapy, CAR-T, siRNAs, targeting agents) preferred.
To Be Considered For This Position, You Must Have:
- Ph.D. or M.S. in pharmacokinetics, pharmaceutical sciences, engineering, applied mathematics, or related disciplines.
- 6+ years pharma/related experience applying mechanism-based PK/PD modeling to guide R&D teams from early discovery through IND-stage clinical development.
Application instructions:
- Apply now.
A Typical Day May Include:
- Independently develop and implement quantitative and mechanistic mathematical PK/PD models for preclinical-to-early clinical translation (human efficacious dose predictions and first-in-human dose selection).
- Advance and shape the strategic direction of modeling and simulation sciences.
- Provide expert support to pre-clinical PK/PD project representatives and R&D teams to design, execute, and interpret in vitro/in vivo quantitative pharmacology studies, including optimizing mouse PK data for translation to nonhuman primate and human PK.
- Integrate and summarize modeling and simulation analyses for multidisciplinary teams.
- Stay current on emerging science and literature; collaborate with Clinical Pharmacology, Quantitative Pharmacology, and R&D experts.
- Present at scientific meetings and publish in scientific journals.
This Role Might Be For You If:
- Experience with modeling/simulation platforms (e.g., Phoenix NLME, NONMEN, Monolix, ADAPT, MATLAB, SimBiology).
- Strong PK foundation: non-compartmental, compartmental, PK/PD, PBPK.
- Ability to work effectively in fast-paced, matrixed environments.
- Ability to learn biological sciences for emerging therapeutic modalities.
- Familiarity with biotherapeutic modalities (monoclonal/bispecific antibodies, gene therapy, CAR-T, siRNAs, targeting agents) preferred.
To Be Considered For This Position, You Must Have:
- Ph.D. or M.S. in pharmacokinetics, pharmaceutical sciences, engineering, applied mathematics, or related disciplines.
- 6+ years pharma/related experience applying mechanism-based PK/PD modeling to guide R&D teams from early discovery through IND-stage clinical development.
Application instructions:
- Apply now.