Associate Director, Pharmacometrics

Role Summary

The Associate Director, Pharmacometrics will support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making from compound nomination through first‑in‑human studies. This role involves conducting PBPK and/or QSP modeling directly and/or working with external partners on a case‑by‑case basis to integrate preclinical, in vitro, biomarker, and early clinical data into predictions that inform IND‑enabling work, dose selection, and study design. Working closely with translational development, DMPK, biology, toxicology, and clinical teams, the Associate Director will help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights. In addition to mechanistic modeling activities, the Associate Director will contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners. This position is well‑suited for a hands‑on modeler who thrives in a collaborative cross‑functional environment and is developing broader program-level and strategic influence.

Responsibilities

• Conduct and contribute to mechanistic modeling (PBPK and/or QSP) to support IND‑enabling decisions, FIH dose selection, and early clinical strategy.
• Integrate preclinical, in vitro, biomarker, and early clinical data to generate human PK/PD and dose predictions.
• Collaborate with translational development, DMPK, biology, tox, and clinical teams to identify and address quantitative needs across key decision points.
• Contribute to the oversight and scientific review of population PK, PK/PD, and exposure–response analyses conducted internally or by CROs.
• Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy.
• Draft, develop and review program‑level quantitative analysis plans under guidance of senior pharmacometric leadership.
• Communicate modeling results clearly to project teams, supporting decision-making and governance discussions.
• Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence.
• Support departmental objectives, mentor junior staff as appropriate, and contribute to the growth of internal mechanistic and translational modeling capabilities.
• Other duties as assigned.

Qualifications

• Pharm.D/Ph.D. or MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of clinical pharmacology principles.
• Significant industry experience (Associate Director: MS and 8 years of experience; PhD/PharmD with 5 years of experience) in clinical pharmacology data analysis and interpretation.
• Experience with PBPK modeling, QSP modeling, and/or integration of AI/ML into clinical pharmacology decision-making.
• Experience interpreting and overseeing population PK and exposure–response analyses.
• Familiarity with all stages of clinical drug development, including experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects.
• Experience working in a cross functional team and matrix environment.
• Strong written, presentation and verbal communication skills.
• Ability to influence business leaders at all levels.
• Critical thinker with strong problem-solving skills.
• Demonstrated ability to apply quantitative methods to complex problems with growing independence.

Skills

• Strong written, presentation, and verbal communication skills in cross-functional settings.
• Ability to influence business leaders at all levels and convey complex quantitative insights clearly.
• Analytical thinking, problem-solving, and quantitative modeling proficiency.
• Collaborative, cross-functional teamwork and mentorship capabilities.

Additional Requirements

• Travel up to 5% of time.
• Physical demands: sit for long periods, occasional walking, and lifting up to 25 lbs; keyboard use; work in a typical office environment.