Associate Director, Pharmacometrician

Role Summary

Develops model informed drug development (MIDD) plans across projects and disease areas to optimize prospective studies, inform drug development strategy and project decision-making in collaboration with partners. Conducts and reports quantitative analyses integrating pharmacokinetics, pharmacodynamics, patient characteristics, and disease states to optimize doses, dosage regimens and study designs throughout clinical drug development. Identifies opportunities where modeling and simulation can advance understanding of pharmacological activity, efficacy and safety. Supports and/or develops pharmacometrics tools, automation workflows, software, and related business processes.

Responsibilities

• Provide support in the development of quantitative methodology, pharmacometrics tools, software, hardware, and/or related business processes.
• With guidance, provide MIDD expertise on multidisciplinary development teams, working closely with clinical pharmacologists, clinicians, and statisticians to create MIDD plans that include assessments of a drug‚Äôs efficacy, safety, and commercial viability.
• Responsible for the planning and execution of quantitative analyses such as population pharmacokinetics, pharmacokinetics/pharmacodynamics, exposure response, disease progression modeling, model-based meta analysis, and decision analysis for multiple analyses supporting a program.
• Prepare formal presentations and written reports to Pfizer standards.
• Contribute to regulatory documents (summary documents, briefing books, regulatory responses).
• Have a good understanding of literature, government guidelines, and internal guidance related to pharmacometrics and MIDD.
• Contribute to the development or improvement of tools, processes and methodology, including involvement in internal cross-functional workgroups or initiatives, external alliances or committees, consortia and academic relationships.

Qualifications

• Required: PhD or equivalent degree with strong quantitative skills (e.g., pharmacometrics, pharmacokinetics, mechanistic modeling/systems pharmacology, statistics).
• Required: 3 years or more of experience in a quantitative field.
• Required: Expertise in analysis and programming software (e.g., Nonmem, R).
• Required: Experience in pharmacometric analyses.
• Required: Good communication skills (written, oral).
• Required: Drug development and/or regulatory experience.
• Required: Publications in relevant discipline.
• Required: Good understanding of Pharmacokinetics, Pharmacodynamics and Statistical Principles.
• Required: Demonstrates breadth of diverse leadership experiences and capabilities, including the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
• Preferred: Experience using Nonmem, R and/or PsN software is preferred.
• Preferred: Candidates from alternative backgrounds (e.g., mathematics, engineering, system biology, medicine) will be considered if they can demonstrate relevant experience and expertise.

Education

• PhD or equivalent degree as noted above in the Qualifications section.

Skills

• Pharmacometric analyses
• Model-informed drug development (MIDD)
• Population PK/PD, exposure‚Äìresponse, disease progression modeling
• Communication of complex quantitative analyses in written and oral formats

Physical/Mental Requirements

• Sitting, ability to perform complex data analyses

Additional Details

• Last date to apply: December 18, 2025
• Work location: Hybrid role requiring live within commuting distance and on-site approximately 2.5 days per week