Associate Director, Pharmacometrician

Role Summary

Associate Director, Pharmacometrician responsible for leading model-informed drug development activities, quantitative analyses integrating pharmacokinetics/pharmacodynamics, and development of MIDD plans across projects. Collaborates with clinical pharmacologists, clinicians, statisticians, and other partners to inform dosing, study design, and decision-making. Contributes to tool development, regulatory documents, and cross-functional initiatives to advance pharmacometrics methods and impact patient care.

Responsibilities

• Provide support in developing quantitative methodologies, pharmacometrics tools, software, hardware, and related processes.
• With guidance, deliver MIDD expertise on multidisciplinary development teams to assess drug efficacy, safety, and commercial viability.
• Plan and execute quantitative analyses (e.g., population PK/PK-PD, exposure‚Äìresponse, disease progression modeling, model-based meta-analysis, decision analysis) to support programs.
• Prepare formal presentations and written reports to Pfizer standards.
• Contribute to regulatory documents (summary documents, briefing books, regulatory responses).
• Stay current with literature, guidelines, and internal guidance related to pharmacometrics and MIDD.
• Contribute to tool/process/methodology development and participate in cross-functional workgroups, alliances, or academic relationships.

Qualifications

• Required: PhD or equivalent with strong quantitative skills (pharmacometrics, pharmacokinetics, systems pharmacology, statistics); 3+ years of experience in a quantitative field; expertise in analysis/programming software (e.g., NONMEM, R); experience in pharmacometric analyses; good written and oral communication; drug development and/or regulatory experience; publications in related discipline; solid understanding of PK/PD and statistics; demonstrated leadership capabilities and ability to influence and coach others.
• Preferred: Experience with NONMEM, R and/or PsN; candidates from math, engineering, systems biology, medicine backgrounds considered if relevant experience is shown.

Additional Requirements

• Sitting; ability to perform complex data analyses.
• Work Location: Hybrid role; reside within commuting distance and on-site ~2.5 days per week.