Associate Director or Director, PBPK & Biopharmaceutics Modeling

Role: Lead the development and application of PBPK/PBBM modeling capabilities at Kymera, focusing on predicting human pharmacokinetics, oral bioavailability, and supporting first-in-human dose selection for oral small molecules, including degraders. Responsibilities include establishing workflows, standards, and best practices; partnering with CMC for formulation optimization; developing IVIVC and dissolution models; and applying models to clinical pharmacology questions such as DDI and special populations. The role requires providing real-time modeling support within multidisciplinary teams, liaising with CROs, and contributing to regulatory submissions. Qualifications: PhD or PharmD in pharmaceutical sciences, with 7+ years of hands-on PBPK/PBBM experience, deep knowledge of ADME/DMPK principles, extensive GastroPlus expertise, and proficiency in scripting languages (R, Python, MATLAB). Experience with modeling challenging developability profiles, regulatory submissions, and collaboration with cross-functional teams is preferred. High-value specifics include focus on oral small molecules, degraders, and translational modeling to inform early clinical development stages. The position reports to the DMPK leadership and involves working in a dynamic environment, emphasizing collaboration and innovation.