Associate Director or Director, PBPK & Biopharmaceutics Modeling
Kymera Therapeutics
August 11, 2026
Remote friendly (Greater Boston)
United States
Clinical Research and Development
How you’ll make an impact:
- Lead and grow Kymera’s PBPK/PBBM capability, defining workflows, standards, best practices, and software strategy.
- Apply translational PBPK/PBBM to predict human PK and oral bioavailability across species, formulations, and dose levels, and support first-in-human dose selection.
- Partner with CMC to support formulation selection and optimization through PBBM.
- Develop IVIVC and mechanistic in vitro-in vivo dissolution models (e.g., DDDPlus) to link drug product performance to in vivo behavior, establish clinically relevant specifications, and support formulation bridging.
- Use PBPK for clinical pharmacology questions (DDIs, food effects, special populations such as pediatrics and organ impairment) to inform study design and dose adjustments.
- Embed in multidisciplinary project teams for real-time study-design support and rapid model iteration.
- Liaise with collaboration partners and CROs to generate data and analyses.
- Represent the DMPK perspective on project teams.
- Prepare reports and summary documents for regulatory submissions and independently respond to health authority questions.
Skills and experience you’ll bring:
- PhD or PharmD (or equivalent) in pharmaceutical sciences, DMPK, pharmacokinetics, chemical/biomedical engineering, or related field; 7+ years hands-on PBPK/PBBM experience.
- Deep ADME/DMPK and biopharmaceutics understanding.
- Significant hands-on GastroPlus experience (required); independently manage and deliver modeling work.
- Build mechanistic absorption and whole-body PBPK models; translate preclinical data to human PK predictions for oral small molecules; provide practical, timely recommendations.
- Experience modeling oral molecules with challenging developability profiles (poor solubility/permeability); beyond-rule-of-five modalities such as targeted protein degraders (preferred).
- Scripting proficiency for data handling, workflow automation, and model QC (R/Python/MATLAB).
- Simcyp modeling experience (preferred).
- Regulatory submissions contributions (IND/NDA/DDI/biopharmaceutics packages) (preferred).
- DMPK project representative experience (strongly preferred).
- Collaborative, fast-paced work style with changing priorities (required).
- Clear communication with specialist and non-specialist stakeholders, including leadership/project management (required).
- Lead and grow Kymera’s PBPK/PBBM capability, defining workflows, standards, best practices, and software strategy.
- Apply translational PBPK/PBBM to predict human PK and oral bioavailability across species, formulations, and dose levels, and support first-in-human dose selection.
- Partner with CMC to support formulation selection and optimization through PBBM.
- Develop IVIVC and mechanistic in vitro-in vivo dissolution models (e.g., DDDPlus) to link drug product performance to in vivo behavior, establish clinically relevant specifications, and support formulation bridging.
- Use PBPK for clinical pharmacology questions (DDIs, food effects, special populations such as pediatrics and organ impairment) to inform study design and dose adjustments.
- Embed in multidisciplinary project teams for real-time study-design support and rapid model iteration.
- Liaise with collaboration partners and CROs to generate data and analyses.
- Represent the DMPK perspective on project teams.
- Prepare reports and summary documents for regulatory submissions and independently respond to health authority questions.
Skills and experience you’ll bring:
- PhD or PharmD (or equivalent) in pharmaceutical sciences, DMPK, pharmacokinetics, chemical/biomedical engineering, or related field; 7+ years hands-on PBPK/PBBM experience.
- Deep ADME/DMPK and biopharmaceutics understanding.
- Significant hands-on GastroPlus experience (required); independently manage and deliver modeling work.
- Build mechanistic absorption and whole-body PBPK models; translate preclinical data to human PK predictions for oral small molecules; provide practical, timely recommendations.
- Experience modeling oral molecules with challenging developability profiles (poor solubility/permeability); beyond-rule-of-five modalities such as targeted protein degraders (preferred).
- Scripting proficiency for data handling, workflow automation, and model QC (R/Python/MATLAB).
- Simcyp modeling experience (preferred).
- Regulatory submissions contributions (IND/NDA/DDI/biopharmaceutics packages) (preferred).
- DMPK project representative experience (strongly preferred).
- Collaborative, fast-paced work style with changing priorities (required).
- Clear communication with specialist and non-specialist stakeholders, including leadership/project management (required).