Associate Director, Operational Excellence
Tango Therapeutics Inc.
October 16, 2026
Full-time
Remote friendly (Boston, MA)
United States
Other
Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Operational Excellence and Training Lead enables scalable, efficient, and inspection‑ready execution across Development by designing standardized processes, building operational capabilities through training, and driving consistent adoption and continuous improvement.
Your Role:
Own and lead end‑to‑end design, implementation, and optimization of assigned process and system across Development
Translate strategic objectives into fit‑for‑purpose, standardized processes that are efficient, scalable, and inspection‑ready
Define process standards, guidance, and performance measures, ensuring clarity of roles and accountability
Develop and deliver training on new/changed processes incl. compliance expectations, and inspection readiness behavior
Design and maintain role‑based and process‑based curricula, including onboarding
Identify inefficiencies, risks, and variability through data analysis and stakeholder input, and lead targeted improvement initiatives
Support functions in adopting new or improved processes through change management, training inputs, and practical guidance
Ensure processes are well documented, consistently applied, and auditable, supporting inspection readiness
Track and report process performance, improvement outcomes, and residual risks to Operational Excellence & Clinical Compliance leadership
Act as a subject‑matter expert and trusted advisor to functional teams on process excellence and operational rigor
Support Leadership in defining and executing the learning and capability‑building strategy for Development functions
Support leadership in building a learning culture that reinforces accountability, consistency, and continuous improvement
What You Bring:
Required Qualifications
Bachelor’s degree required (Life Sciences, or related field)
Advanced degree preferred (e.g., MBA, MSc)
Certification or formal training in Operational Excellence, Lean, Six Sigma, or Process Improvement preferred
Required Experience
8–10+ years’ experience in operational excellence, process improvement, training, or operational leadership within a regulated life sciences or clinical development environment
Proven experience owning and implementing end‑to‑end processes or systems across multiple functions
Hands‑on experience designing and delivering process and role‑based training
Experience supporting audit and inspection readiness, including documentation and behavioral readiness
Required Competencies
End‑to‑end process design, standardization, and optimization
Lean / continuous improvement methodologies
Training design, curriculum development, and adult learning principles
Process documentation (SOPs, guidance, work instructions)
Process performance metrics, KPIs, and dashboarding
Understanding compliance and inspection expectations in regulated environments.
Strong systems thinker able to translate strategy into execution
Excellent facilitation, communication, and stakeholder‑engagement skills
Ability to influence and drive adoption without direct authority
Pragmatic change leader with strong execution discipline
Trusted advisor mindset with high credibility and accountability
Collaborative, service‑oriented, and improvement‑focused
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Salary range
$164,000 — $246,000 USD
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Operational Excellence and Training Lead enables scalable, efficient, and inspection‑ready execution across Development by designing standardized processes, building operational capabilities through training, and driving consistent adoption and continuous improvement.
Your Role:
Own and lead end‑to‑end design, implementation, and optimization of assigned process and system across Development
Translate strategic objectives into fit‑for‑purpose, standardized processes that are efficient, scalable, and inspection‑ready
Define process standards, guidance, and performance measures, ensuring clarity of roles and accountability
Develop and deliver training on new/changed processes incl. compliance expectations, and inspection readiness behavior
Design and maintain role‑based and process‑based curricula, including onboarding
Identify inefficiencies, risks, and variability through data analysis and stakeholder input, and lead targeted improvement initiatives
Support functions in adopting new or improved processes through change management, training inputs, and practical guidance
Ensure processes are well documented, consistently applied, and auditable, supporting inspection readiness
Track and report process performance, improvement outcomes, and residual risks to Operational Excellence & Clinical Compliance leadership
Act as a subject‑matter expert and trusted advisor to functional teams on process excellence and operational rigor
Support Leadership in defining and executing the learning and capability‑building strategy for Development functions
Support leadership in building a learning culture that reinforces accountability, consistency, and continuous improvement
What You Bring:
Required Qualifications
Bachelor’s degree required (Life Sciences, or related field)
Advanced degree preferred (e.g., MBA, MSc)
Certification or formal training in Operational Excellence, Lean, Six Sigma, or Process Improvement preferred
Required Experience
8–10+ years’ experience in operational excellence, process improvement, training, or operational leadership within a regulated life sciences or clinical development environment
Proven experience owning and implementing end‑to‑end processes or systems across multiple functions
Hands‑on experience designing and delivering process and role‑based training
Experience supporting audit and inspection readiness, including documentation and behavioral readiness
Required Competencies
End‑to‑end process design, standardization, and optimization
Lean / continuous improvement methodologies
Training design, curriculum development, and adult learning principles
Process documentation (SOPs, guidance, work instructions)
Process performance metrics, KPIs, and dashboarding
Understanding compliance and inspection expectations in regulated environments.
Strong systems thinker able to translate strategy into execution
Excellent facilitation, communication, and stakeholder‑engagement skills
Ability to influence and drive adoption without direct authority
Pragmatic change leader with strong execution discipline
Trusted advisor mindset with high credibility and accountability
Collaborative, service‑oriented, and improvement‑focused
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Salary range
$164,000 — $246,000 USD