Associate Director, Oligonucleotide Development

Role: Lead oligonucleotide process development for PMO and ASO payloads, overseeing full lifecycle from preclinical to GMP manufacturing. Responsibilities: define and optimize scalable synthesis and analytical strategies, manage external CDMOs, ensure process robustness, and contribute to global regulatory filings (IND, IMPD). Serve as technical lead in cross-functional teams, ensuring compliance with GxP standards, authoring key regulatory documents, and driving process innovation. Requirements: PhD or equivalent in a scientific discipline; 8+ years in oligonucleotide process chemistry, CMC strategy development, and CDMO management. Expertise in PMO and ASO synthesis, purification, and analytical characterization, with proven success in regulatory submissions for IND/IMPD. HighValue: oligonucleotide therapeutics (PMO, ASO), CMC lifecycle, GMP manufacturing, global regulatory filings, CDMO oversight. WorkSetup: onsite in Waltham, MA, 4-5 days/week.