Associate Director, in Vivo Pharmacology
Crinetics Pharmaceuticals
2 months ago
On-site
San Diego, CA
Clinical Research and Development
Position Summary
- Provide in vivo pharmacology support to Endocrine Discovery teams by designing, conducting, and interpreting experiments to demonstrate efficacy and evaluate safety of novel nonpeptides in animal models.
Essential Job Functions and Responsibilities
- Lead the Endocrine Discovery In Vivo Pharmacology team to plan, design, conduct, and interpret in vivo experiments to evaluate efficacy, pharmacokinetics, and safety of therapeutic candidate molecules for endocrine disease drug discovery.
- Lead and supervise Scientists and Research Associates.
- Serve as Program Lead to guide, coordinate, and implement cross-functional activities for Endocrine Discovery programs.
- Act as in vivo pharmacology subject matter expert for other functional areas.
- Oversee vivarium operations and IACUC.
- Troubleshoot and perform accurate data analysis on in vivo studies; proactively improve/adapt methods and techniques.
- Analyze and present data using Prism, Excel, MS Office, or comparable software.
- Present findings at team/cross-functional meetings and scientific conferences.
- Author scientific publications and write in vivo pharmacology reports to support regulatory filings.
- Ensure compliance with established laboratory practices and procedures (lab notebooks, computer files, quality/regulatory guidelines, safety standards).
- Verify data and ensure accuracy for notebooks, protocols, reports, and regulatory filings.
- Work some weekends and holidays as needed; other duties as assigned.
Required Qualifications
- Ph.D. in Biology, Endocrinology, Neuroscience, Behavioral Pharmacology, Physiology, or related discipline; minimum 8+ years relevant experience and 7+ years supervisory experience.
- OR BS/MS: minimum 10 years significant and relevant experience and 7+ years supervisory experience.
- Experience designing and conducting rodent in vivo pharmacology studies.
- Experience developing in vivo models of endocrine disease.
- Experience working in the pharmaceutical industry.
- Hands-on rodent handling and in vivo skills (IV, PO, SC dosing; blood/tissue collection; necropsy, etc.).
- Proficiency with basic surgical techniques.
- Independent; able to follow experimental designs and develop new methods/protocols based on literature.
- Ability to communicate and present research results.
- Strong work ethic; enthusiastic for animal and laboratory work.
- Detail-oriented, punctual, reliable; available on weekends when necessary.
- Strong written and verbal communication; effective multidisciplinary teamwork.
- Ability to work in a fast-paced environment and adapt to change.
Preferred Qualifications
- Experience managing external collaborations and outsourced studies.
- Experience with non-GLP rodent toxicity studies.
- Experience in program management/leadership.
Skills/Tools
- Prism, Excel, MS Office (or comparable software); data analysis and presentation.
Work Environment / Additional Details
- Vivarium and biology/chemical laboratory experience; environmental health and safety requirements apply.
- Travel up to 5% of the time.
Benefits / Compensation (as stated)
- Salary range: $160,000–$200,000.
- Discretionary annual target bonus; stock options; ESPP; 401k match.
- Medical, dental, vision, basic life insurance; 20 days PTO; 10 paid holidays; winter company shutdown.
- Provide in vivo pharmacology support to Endocrine Discovery teams by designing, conducting, and interpreting experiments to demonstrate efficacy and evaluate safety of novel nonpeptides in animal models.
Essential Job Functions and Responsibilities
- Lead the Endocrine Discovery In Vivo Pharmacology team to plan, design, conduct, and interpret in vivo experiments to evaluate efficacy, pharmacokinetics, and safety of therapeutic candidate molecules for endocrine disease drug discovery.
- Lead and supervise Scientists and Research Associates.
- Serve as Program Lead to guide, coordinate, and implement cross-functional activities for Endocrine Discovery programs.
- Act as in vivo pharmacology subject matter expert for other functional areas.
- Oversee vivarium operations and IACUC.
- Troubleshoot and perform accurate data analysis on in vivo studies; proactively improve/adapt methods and techniques.
- Analyze and present data using Prism, Excel, MS Office, or comparable software.
- Present findings at team/cross-functional meetings and scientific conferences.
- Author scientific publications and write in vivo pharmacology reports to support regulatory filings.
- Ensure compliance with established laboratory practices and procedures (lab notebooks, computer files, quality/regulatory guidelines, safety standards).
- Verify data and ensure accuracy for notebooks, protocols, reports, and regulatory filings.
- Work some weekends and holidays as needed; other duties as assigned.
Required Qualifications
- Ph.D. in Biology, Endocrinology, Neuroscience, Behavioral Pharmacology, Physiology, or related discipline; minimum 8+ years relevant experience and 7+ years supervisory experience.
- OR BS/MS: minimum 10 years significant and relevant experience and 7+ years supervisory experience.
- Experience designing and conducting rodent in vivo pharmacology studies.
- Experience developing in vivo models of endocrine disease.
- Experience working in the pharmaceutical industry.
- Hands-on rodent handling and in vivo skills (IV, PO, SC dosing; blood/tissue collection; necropsy, etc.).
- Proficiency with basic surgical techniques.
- Independent; able to follow experimental designs and develop new methods/protocols based on literature.
- Ability to communicate and present research results.
- Strong work ethic; enthusiastic for animal and laboratory work.
- Detail-oriented, punctual, reliable; available on weekends when necessary.
- Strong written and verbal communication; effective multidisciplinary teamwork.
- Ability to work in a fast-paced environment and adapt to change.
Preferred Qualifications
- Experience managing external collaborations and outsourced studies.
- Experience with non-GLP rodent toxicity studies.
- Experience in program management/leadership.
Skills/Tools
- Prism, Excel, MS Office (or comparable software); data analysis and presentation.
Work Environment / Additional Details
- Vivarium and biology/chemical laboratory experience; environmental health and safety requirements apply.
- Travel up to 5% of the time.
Benefits / Compensation (as stated)
- Salary range: $160,000–$200,000.
- Discretionary annual target bonus; stock options; ESPP; 401k match.
- Medical, dental, vision, basic life insurance; 20 days PTO; 10 paid holidays; winter company shutdown.