Associate Director, In Vitro Pharmacology
Crinetics Pharmaceuticals
6 hours ago
On-site
San Diego, CA
$160,000 - $200,000 USD yearly
Clinical Research and Development
Position Summary
- Lead and oversee in vitro pharmacology activities, including support for lead optimization campaigns, mechanism-of-action studies, and new target initiatives within endocrinology.
Essential Job Functions and Responsibilities
- Provide scientific leadership and hands-on management of a team of scientists.
- Design, develop, validate, and execute in vitro assays supporting drug discovery programs.
- Organize experimental work to deliver critical in vitro data supporting multiple programs.
- Oversee, troubleshoot, and perform accurate data analysis with scientific integrity and quality.
- Represent the function and lead cross-functional Program Teams.
- Interpret and communicate results (written and oral) to interdisciplinary teams.
- Participate in strategic planning for departmental growth, organization, and evaluation of new targets.
- Prepare technical reports supporting program reviews, publications, and IND submissions.
- Identify and evaluate new research targets in therapeutic areas of interest.
- Ensure compliance with company practices and procedures (laboratory notebooks, computer files, quality/regulatory guidelines, safety standards).
Required Qualifications
- Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with 8+ years relevant experience; OR BS/MS with 10+ years relevant experience.
- 7+ years in drug discovery and small molecule pharmacology at therapeutically relevant GPCRs (or related field).
- 7+ years of supervisory experience.
- Extensive proficiency with biochemical, cellular, and/or radioligand binding assay systems; ensure high-quality in vitro assay data.
- Ability to independently determine in vitro pharmacologic methods/procedures to achieve program goals.
- Strong experimental design, problem-solving, and data analysis; independently establish in vitro pharmacologic approaches.
- Deep understanding of in vitro pharmacology theory/models/mechanisms/design, particularly with GPCRs.
- Independent and able to follow established experimental designs and develop new methods/protocols/technologies from literature.
- Experience managing and daily supervising scientific staff; experience in program management/leadership.
- Strong written and verbal communication; ability to work in multidisciplinary teams.
- Experience writing reports and technical regulatory documents.
- Detail-oriented, punctual, reliable; able to work in fast-paced environments and adapt to change.
Physical Demands/Work Environment (highlights)
- Sit at desk for long periods; occasional telephone/keyboard use.
- Some walking and lifting up to 25 lbs (as needed).
- Biology/chemical lab environment experience; environmental health and safety requirements.
Travel
- Up to 5% of time.
Benefits/Compensation (as stated)
- Salary range: $160,000 - $200,000.
- Total rewards may include discretionary annual target bonus, stock options, ESPP, and 401k match; medical/dental/vision/basic life insurance; 20 days PTO; 10 paid holidays; winter company shutdown.
- Lead and oversee in vitro pharmacology activities, including support for lead optimization campaigns, mechanism-of-action studies, and new target initiatives within endocrinology.
Essential Job Functions and Responsibilities
- Provide scientific leadership and hands-on management of a team of scientists.
- Design, develop, validate, and execute in vitro assays supporting drug discovery programs.
- Organize experimental work to deliver critical in vitro data supporting multiple programs.
- Oversee, troubleshoot, and perform accurate data analysis with scientific integrity and quality.
- Represent the function and lead cross-functional Program Teams.
- Interpret and communicate results (written and oral) to interdisciplinary teams.
- Participate in strategic planning for departmental growth, organization, and evaluation of new targets.
- Prepare technical reports supporting program reviews, publications, and IND submissions.
- Identify and evaluate new research targets in therapeutic areas of interest.
- Ensure compliance with company practices and procedures (laboratory notebooks, computer files, quality/regulatory guidelines, safety standards).
Required Qualifications
- Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with 8+ years relevant experience; OR BS/MS with 10+ years relevant experience.
- 7+ years in drug discovery and small molecule pharmacology at therapeutically relevant GPCRs (or related field).
- 7+ years of supervisory experience.
- Extensive proficiency with biochemical, cellular, and/or radioligand binding assay systems; ensure high-quality in vitro assay data.
- Ability to independently determine in vitro pharmacologic methods/procedures to achieve program goals.
- Strong experimental design, problem-solving, and data analysis; independently establish in vitro pharmacologic approaches.
- Deep understanding of in vitro pharmacology theory/models/mechanisms/design, particularly with GPCRs.
- Independent and able to follow established experimental designs and develop new methods/protocols/technologies from literature.
- Experience managing and daily supervising scientific staff; experience in program management/leadership.
- Strong written and verbal communication; ability to work in multidisciplinary teams.
- Experience writing reports and technical regulatory documents.
- Detail-oriented, punctual, reliable; able to work in fast-paced environments and adapt to change.
Physical Demands/Work Environment (highlights)
- Sit at desk for long periods; occasional telephone/keyboard use.
- Some walking and lifting up to 25 lbs (as needed).
- Biology/chemical lab environment experience; environmental health and safety requirements.
Travel
- Up to 5% of time.
Benefits/Compensation (as stated)
- Salary range: $160,000 - $200,000.
- Total rewards may include discretionary annual target bonus, stock options, ESPP, and 401k match; medical/dental/vision/basic life insurance; 20 days PTO; 10 paid holidays; winter company shutdown.