Associate Director, External Manufacturing

Role: Associate Director, External Manufacturing, leading strategic partnerships with 1–3 CDMOs supporting RNAi-based therapeutics production. Responsibilities: manage end-to-end relationships, oversee technology transfer, GMP supply, and lifecycle performance for drug substance, conjugation, and drug product; coordinate cross-functional teams in Process Development, Quality, Regulatory, Supply Chain, and Clinical Operations; ensure compliance, quality, and timely delivery for clinical and commercial supply; support regulatory filings and inspection readiness. Requirements: PhD/MS/BSc in Chemistry, Chemical Engineering, Biochemistry, or related; 8+ years in biopharmaceutical operations, with expertise in external manufacturing, preferably with oligonucleotides or targeted RNA delivery (GalNAc); proven CDMO management, technology transfer, GMP oversight, and regulatory support experience. High-Value: RNAi therapeutics, oligonucleotide synthesis, conjugation technologies, late-stage clinical and commercial readiness, GMP compliance, regulatory interactions, cross-functional leadership. WorkSetup: onsite in Pasadena, CA, with a 5-day office requirement.