Associate Director, Drug Product - CMC

Role: Associate Director of Drug Product within Centessa's CMC group, supporting early-stage small molecule programs, particularly for neurological indications like narcolepsy. Responsibilities: oversee nonclinical and clinical formulation development, manage CROs/CDMOs, guide physiochemical characterization, pre-formulation, stability, and compatibility studies; support clinical formulation efforts; author and review development documentation; coordinate shipments and regulatory submissions; collaborate with cross-functional teams (discovery, nonclinical, clinical, regulatory). Requirements: BS/MS in Pharmaceutical Sciences or related; PhD preferred; 10+ years in small molecule formulation development supporting Phase I-III; expertise in poorly soluble (BCS II/IV) compounds, liquid and solid dosage forms, analytical techniques (HPLC, XRPD, DSC, TGA, DVS); experience managing external vendors and working within cGMP standards. HighValue: small molecule drugs, neurological indications (narcolepsy, hypersomnia), Phase I-III, nonclinical and clinical formulation, cGMP, vendor oversight. WorkSetup: based in US, with occasional domestic/international travel (5-10%).