Associate Director, Drug Discovery Toxicology

Role Summary

Associate Director, Drug Discovery Toxicology leading safety assessment for Recursion programs from early discovery through candidate selection and beyond. Provide scientific expertise and leadership to cross-functional teams, contributing to target assessment and optimization of novel molecules using molecular, cellular, and in vivo technologies to maximize predictive safety science and investigative toxicology.

Responsibilities

• Represent Toxicology as the Subject Matter Expert on cross-functional project teams within Discovery
• Provide expert input, guidance and strategy on project safety assessments, with a specific focus on discovery projects
• Act as a key resource for early safety assessment during the drug discovery phase, providing scientific knowledge and expertise to cross-functional project teams
• Use established toxicology screening strategies to predict, assess and mitigate target- and drug-related safety risks in support of the drug discovery portfolio
• Refine and implement innovative experimental strategies and use the data to assess and/or provide mechanistic understanding of safety issues
• Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment
• Prepare verbal and written summaries for internal discussions. Work with the Discovery teams to develop optimal strategies to address specific safety issues within the project teams
• Present summary data to project teams, Recursion senior leadership and external partners as needed

Qualifications

• Preferred: DVM, PharmD, PhD in toxicology, Pathology, Physiology, Biochemistry or related disciplines with emphasis on Oncology/Immunology. Board Certification in Toxicology (DABT/ERT) is a plus
• Required: 7+ years experience in safety sciences in the Biotech/Pharma industry
• Required: Experience in project team membership as a toxicology representative in a matrix environment
• Required: Experience with in silico and in vitro safety assessment
• Preferred: Experience with in vivo safety assessment
• Required: In-depth knowledge of discovery toxicology, and experience designing and critically evaluating results of exploratory toxicology studies
• Preferred: Experience of secondary pharmacology assessment
• Required: Understanding of in vitro to in vivo translation of potential toxicities and implications for human safety
• Required: Broad background in novel methods of identifying potential toxicities and developing risk mitigation plans
• Preferred: Experience with the use of AI tools to predict toxicology endpoints
• Required: Highly motivated scientist who can work independently with excellent oral/written communication skills

Skills

• Strong communication and collaboration across multidisciplinary teams

Education

• Doctoral or professional degree in toxicology or related field (DVM, PharmD, PhD) preferred