Associate Director, Computational Chemistry

Role Summary

Associate Director, Computational Chemistry. Lead computational chemistry efforts to advance drug discovery, provide computational expertise within a multidisciplinary team, and drive project progression across research sites. Implement and execute innovative computational methodologies and tools to support drug discovery efforts.

Responsibilities

• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
• Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
• Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects.
• Build and develop a strong team of Computational Chemists to high productivity levels.
• Lead and execute novel scientific projects and platform initiatives.

Qualifications

• PhD degree in a scientific discipline with 7+ years of Industry (pharma/biotech) drug discovery experience required
• Significant industry experience contributing as Computational Chemist on drug discovery projects
• Strong impact in progressing discovery projects from hits to clinical leads
• Extensive knowledge and experience in using tools for hit identification and computational strategies to inform, influence, and prioritize compound designs for potency/rigor and ADME/Tox endpoints
• Ability to integrate generative chemistry methods and modern ML/AI applications in small molecule drug discovery
• Proficiency with state-of-the-art Computational Chemistry software

Skills

• Expertise in docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, and diversity analysis
• Experience providing computational strategies to inform and prioritize compound designs
• Strong leadership and ability to supervise and develop teams

Education

• PhD in a scientific discipline (required)

Additional Requirements

• The position is based in Cambridge, MA; hybrid work arrangement