Associate Director, Clinical Scientist
Madrigal Pharmaceuticals
July 01, 2026
Remote friendly (Conshohocken, PA)
United States
Clinical Research and Development
Associate Director, Clinical Scientist
Key Responsibilities
- Contribute to the design and development of clinical trial protocols (scientific rationale, objectives, endpoints, eligibility criteria).
- Author/review key clinical documents (investigator brochures, informed consent forms, clinical study reports, regulatory submissions).
- Provide scientific input during trial execution (protocol amendments, site engagement, data reviews, ongoing study support).
- Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure trial quality and data integrity.
- Conduct data reviews and support data interpretation with biostatistics and the medical team.
- Support preparation of documents for regulatory submissions, health authority meetings, and internal governance.
- Stay current on MASH/NASH therapeutic trends, competitive landscape, and regulatory guidance.
- Participate in cross-functional meetings; contribute to development strategies and timelines.
Experience and Professional Qualifications (Required)
- Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field (Master’s with relevant experience may be considered).
- 2+ years clinical development or clinical research experience in pharma/biotech.
- 10+ years relevant experience.
- Solid knowledge of ICH/GCP and global clinical trial regulations.
- Ability to synthesize complex scientific data and communicate clearly.
- Excellent verbal and written communication.
- Collaborative mindset with strong organizational and project management abilities.
Preferred Attributes
- Experience in fast-paced biotech with small, agile teams.
- Familiarity with liver disease endpoints (histology, imaging, non-invasive biomarkers).
- Experience supporting regulatory interactions/submissions.
Benefits
- Base pay/bonus/equity; eligible for comprehensive benefits (flexible PTO, medical/dental/vision, life/disability, 401(k) offerings, and other voluntary benefits).
Key Responsibilities
- Contribute to the design and development of clinical trial protocols (scientific rationale, objectives, endpoints, eligibility criteria).
- Author/review key clinical documents (investigator brochures, informed consent forms, clinical study reports, regulatory submissions).
- Provide scientific input during trial execution (protocol amendments, site engagement, data reviews, ongoing study support).
- Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure trial quality and data integrity.
- Conduct data reviews and support data interpretation with biostatistics and the medical team.
- Support preparation of documents for regulatory submissions, health authority meetings, and internal governance.
- Stay current on MASH/NASH therapeutic trends, competitive landscape, and regulatory guidance.
- Participate in cross-functional meetings; contribute to development strategies and timelines.
Experience and Professional Qualifications (Required)
- Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field (Master’s with relevant experience may be considered).
- 2+ years clinical development or clinical research experience in pharma/biotech.
- 10+ years relevant experience.
- Solid knowledge of ICH/GCP and global clinical trial regulations.
- Ability to synthesize complex scientific data and communicate clearly.
- Excellent verbal and written communication.
- Collaborative mindset with strong organizational and project management abilities.
Preferred Attributes
- Experience in fast-paced biotech with small, agile teams.
- Familiarity with liver disease endpoints (histology, imaging, non-invasive biomarkers).
- Experience supporting regulatory interactions/submissions.
Benefits
- Base pay/bonus/equity; eligible for comprehensive benefits (flexible PTO, medical/dental/vision, life/disability, 401(k) offerings, and other voluntary benefits).