Associate Director, Biometrics
Ionis Pharmaceuticals, Inc.
August 19, 2026
Remote friendly (Carlsbad, CA)
United States
Clinical Research and Development
ASSOCIATE DIRECTOR, BIOMETRICS
Responsibilities:
- Provide statistical leadership and independent guidance for assigned clinical development programs/projects, including study design, analysis, interpretation, and development strategy.
- Serve as the statistical lead on cross-functional study and project teams; recommend solutions to complex statistical issues.
- Lead statistical strategy and execution across assigned studies to ensure scientific rigor, consistency, and alignment with regulatory and industry standards.
- Design clinical trials and provide statistical guidance.
- Provide sample size estimates.
- Write statistical sections of study protocols, statistical analysis plans (SAPs), and study reports.
- Develop clinical trial randomization.
- Review study protocols, CRFs, database structures, study reports, and annual reports.
- Lead review and discussion of SAP.
- Oversee CRO statistical activities and deliverables (quality, timelines, and SAP implementation).
- Maintain study documentation of statistical analyses and supportive documents.
Requirements:
- PhD in Statistics/Biostatistics (or related) with at least 5 years relevant experience, or Master’s with at least 8 years relevant experience.
- Proficient with SAS and other statistical software (e.g., R).
- Proven knowledge of CDISC standards and application to projects.
- Advanced oral and written communication skills.
Work Location: Carlsbad, CA (onsite preferred); remote may be considered; relocation assistance available for eligible candidates.
Application: Apply via ionis.com; reference requisition # IONIS004094.
Responsibilities:
- Provide statistical leadership and independent guidance for assigned clinical development programs/projects, including study design, analysis, interpretation, and development strategy.
- Serve as the statistical lead on cross-functional study and project teams; recommend solutions to complex statistical issues.
- Lead statistical strategy and execution across assigned studies to ensure scientific rigor, consistency, and alignment with regulatory and industry standards.
- Design clinical trials and provide statistical guidance.
- Provide sample size estimates.
- Write statistical sections of study protocols, statistical analysis plans (SAPs), and study reports.
- Develop clinical trial randomization.
- Review study protocols, CRFs, database structures, study reports, and annual reports.
- Lead review and discussion of SAP.
- Oversee CRO statistical activities and deliverables (quality, timelines, and SAP implementation).
- Maintain study documentation of statistical analyses and supportive documents.
Requirements:
- PhD in Statistics/Biostatistics (or related) with at least 5 years relevant experience, or Master’s with at least 8 years relevant experience.
- Proficient with SAS and other statistical software (e.g., R).
- Proven knowledge of CDISC standards and application to projects.
- Advanced oral and written communication skills.
Work Location: Carlsbad, CA (onsite preferred); remote may be considered; relocation assistance available for eligible candidates.
Application: Apply via ionis.com; reference requisition # IONIS004094.