Associate Director, ADC platform in Oncology Drug Discovery

Role: Associate Director leading scientific strategy for ADC discovery, focusing on payload selection, linker design, and conjugation technologies to drive next-generation targeted therapies. Responsibilities: develop and evaluate innovative ADC platforms by integrating payload mechanisms, resistance biology, and tolerability; collaborate with chemistry, biology, and translational teams to advance ADC programs; assess and prioritize novel payloads and linkers; provide biology-driven insights on mechanisms of action and tumor context; design experiments to evaluate ADC activity, stability, and pharmacology; contribute to platform strategy and represent payload/linker expertise in cross-functional and external collaborations; monitor scientific and competitive landscapes; mentor team members. Requirements: Ph.D. in cancer biology, pharmacology, chemical biology, biochemistry, or related field; 5–10 years industry experience in ADC discovery or targeted oncology therapeutics; extensive knowledge of ADC payloads, linker chemistry, stability, and conjugation techniques; deep understanding of ADC biology including internalization, trafficking, and payload release; proven ability to integrate multidisciplinary data and influence program decisions; strong communication and leadership skills. High-Value: ADC modality, payload and linker innovation, targeted cancer therapies, oncology drug discovery, industry experience. Location: Cambridge, MA; role involves cross-functional collaboration and leadership in a discovery environment.