Assistant Director/Associate Director, Toxicology

Role: Associate Director, Toxicology at Ionis leads nonclinical safety assessments of drug candidates, providing strategic toxicology input for program progression. Responsibilities include designing and interpreting pharmacology and toxicology studies (GLP and non-GLP), managing CRO outsourced studies, synthesizing safety data, developing regulatory strategies, authoring and reviewing regulatory submissions, and communicating safety findings to internal teams and external stakeholders. The role involves representing Ionis at scientific forums and contributing to peer-reviewed publications. Requirements: Master’s or Ph.D. in Toxicology or related life sciences, with 5+ years (Ph.D.) or 8+ years (Master’s) in nonclinical safety within pharma or biotech, including experience managing CRO studies, data interpretation, and regulatory document authoring. Preferred: DABT certification or interest in obtaining it. High-value: Focus on RNA-targeted therapeutics, strong emphasis on regulatory interactions, GLP and non-GLP study oversight, and cross-functional collaboration within a matrixed environment. Location: Onsite in Carlsbad, CA.