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Analytical Chemistry Principal Research Associate

Vertex Pharmaceuticals
June 26, 2026
On-site
San Diego, CA
Clinical Research and Development
Principal Research Associate, Analytical Chemistry (On-site)

Key Duties And Responsibilities
- Purify small molecules using HPLC and SFC in support of medicinal chemistry programs.
- Develop and optimize SFC purification methods, including chiral and achiral separations.
- Perform analytical testing to confirm purity, identity, and quality of compounds.
- Run small molecule property assays such as solubility, lipophilicity, and stability assessments.
- Partner closely with medicinal chemists to support project timelines and compound delivery needs.
- Troubleshoot purification and assay issues and help improve lab workflows.
- Maintain accurate records and clearly communicate results to project teams.
- Support routine operation and maintenance of chromatography instruments.

Knowledge And Skills
- Small molecule purification and characterization
- Laboratory data systems and electronic lab notebooks
- Familiarity with discovery informatics or compound tracking systems
- Experience with software development, scripting, or coding
- Ability to work effectively in cross-functional teams
- Strong written and verbal communication skills
- Ability to work independently, manage priorities, and drive technical work with limited oversight

Education And Experience
- Requires a Masterโ€™s and 2+ years, or a Bachelorโ€™s and 5+ years of experience, or equivalent combination
- Experience supporting small molecule discovery or medicinal chemistry programs
- Strong hands-on experience with HPLC and/or SFC purification

Pay Range
- $85,700 - $128,500