Advisor / Sr. Advisor - Peptide Phage Display (San Diego, CA)

Role Summary

Advisor / Sr. Advisor - Peptide Phage Display (San Diego, CA) is a technical lead position in the Peptide Discovery Team within Biotechnology Discovery Research. The role focuses on designing and executing the next generation of peptide phage display, training a team of scientists, and leading screening projects to accelerate the development of cyclic peptide hits for therapeutic applications.

Responsibilities

• Apply expertise of molecular biology, genetic engineering, and chemistry to build a robust multicyclic peptide phage display platform.
• Execute the multicyclic peptide phage display platform for discovery and optimization of peptide hits for a given biological target.
• Develop new methods and technologies to strengthen the platform.
• Train junior scientists on the build and execution of multicyclic peptide phage display platform.
• Lead screening projects and collaborate with experts in organic chemistry, computational science, and structural biology.
• Incorporate knowledge to improve peptide properties such as binding affinity and physicochemical properties.
• Collaborate with peptide chemists to implement rational SAR strategies to improve pharmaceutical properties of therapeutic peptide leads.
• Resolve issues at the interface of peptide discovery, peptide engineering, pharmaceutical developability and formulation, and biology.

Qualifications

• Ph.D. in chemistry, biochemistry, or molecular biology with a strong focus on peptides.
• 2+ years of experience in a biotechnology/pharmaceutical company with demonstrated leadership in peptide discovery and a track record of advancing peptide-based therapeutics from concept to clinical development.

Additional Skills

• Supervisory experience directing junior scientists in experimental design and execution.
• Experience with state-of-the-art peptide phage display platforms evidenced by publications or patents.
• Experience with biochemical and cell assay design and development to support peptide discovery.
• Experience triaging and validating peptide actives after selection campaigns.
• Understanding of compound physical chemistry models and their relation to ADME properties.
• Appreciation of peptide formulation requirements and experience incorporating developability assessment in optimization.
• Strong cross-functional collaboration, and excellent organizational, communication, and presentation skills.