Advisor/Sr. Advisor Bioconjugation Process Development

Role Summary

Advisor/Sr. Advisor Bioconjugation Process Development.

Responsibilities

• Establish a productive laboratory program by personally conducting and managing internal and external research plans, collaborate with teammates to analyze the results, form conclusions, propose logical next steps, and report findings to a larger team.
• Thrive at the interface between disciplines and departments to quickly move from one scientific challenge to another while navigating ambiguity.
• Perform fundamental and detailed studies of each process step for bioconjugation development.
• Propose and test new methods to achieve bioconjugation and bioconjugate development. Collaborate and share findings with discovery scientists.
• Embrace and celebrate diversity by using a relevant and unique background and set of experiences to provide new ideas to deliver innovative solutions. Strong communication (oral and written), organizational, and leadership skills are expected.
• Bring new and useful concepts, methods, and ideas for how research can be improved and share these to make our group better.
• Engage externally through conference attendance, presentations and publications. Identify, partner, and develop process innovations from the outside to complement existing capabilities and areas of focus and incorporate these across the portfolio.
• Demonstrate learning agility across modalities (e.g. small molecule, peptide and oligonucleotide).
• Help drive and develop the commercial manufacturing strategy and collaborate with manufacturing partners to deliver robust processes that are ultimately suitable for large-scale manufacturing.

Qualifications

• PhD in synthetic organic chemistry, biochemistry, chemical biology, or related field or MS in related field with 5+ years of relevant industrial experience.
• Postdoctoral experience in a field related to bioconjugation.
• Experience with small molecule organic synthesis, knowledge of reaction mechanisms, and design of reactions.
• Experience with performing bioconjugation reactions at small-scale.
• Knowledge of basic antibody class, structure, and function.
• Knowledge of and hands-on experience with analytical methods used for small molecules and biomolecules (RP-HPLC, SEC, IEX, HIC, LC-MS, CE-SDS).
• Experience with handling small quantities of highly potent small molecules in a safe manner.
• Good interpersonal skills and a persistent tendency for collaboration
• Demonstrated self-initiative and appropriate risk-taking behaviors.
• Ability to prioritize multiple activities and thrive in a setting that requires quick movement between scientific challenges and comfort with ambiguity.
• An active scientific curiosity and interest for complementary disciplines within the pharmaceutical industry.
• Demonstrated track record of authoring and contributing to external presentations and publications.
• Experience with preparative-scale ADC or ARC purifications (TFF, IEX etc.).

Skills

• Synthetic organic chemistry
• Bioconjugation
• Laboratory program management
• Cross-functional collaboration
• Technical communication (oral and written)
• Process development and optimization
• Analytical techniques (RP-HPLC, SEC, IEX, HIC, LC-MS, CE-SDS)

Education

• PhD in synthetic organic chemistry, biochemistry, chemical biology, or related field OR MS in related field with 5+ years of industrial experience.

Additional Requirements

• Travel: 0‚Äì10%
• Located in Indianapolis, Indiana, Lilly Technology Center ‚Äì North.
• Full-time salaried position.