Advisor/Senior Advisor, Purification Development - Bioconjugates

Role Summary

Advisor/Senior Advisor, Purification Development - Bioconjugates

Responsibilities

• As a scientist in the Purification Development group, you will:
• Identify and develop new purification technologies
• Design optimized downstream drug substance processes for new biologic candidates with particular focus on complex bioconjugates.
• Maintain accurate records and interpret data to provide detailed information and analysis on the execution of experiments.
• Employ strategic thinking to overcome technical hurdles and oversee process and technical transfer to GMP manufacturing facilities, as they make their way from discovery to the clinic.
• Write technical reports, tech transfer documents and give presentations to summarize development activities.
• Have flexibility to accept new projects and challenges.
• Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability.

Qualifications

• PhD in Chemical Engineering or related degree focused on biological separation sciences OR
• MS in Chemistry, Chemical Engineering, or related degree with at least 5 years relevant experience in leading protein purification/process development OR
• BS in Chemistry, Chemical Engineering, or related degree with at least 8 years relevant experience in leading protein purification/process development
• Hands-on experience with bioconjugate purification

Additional Preferences

• Ability to exhibit a high level of attention to detail, a quality-minded approach to experimental design and record keeping.
• Effective oral and written communication skills.
• Strong laboratory skills
• Experience developing, optimizing, scaling, and tech transferring conjugation reactions for mAbs or other proteins (e.g., PEGylation, ADCs, antibody-oligonucleotide conjugates)
• Experience with bioconjugate purification challenges including maintaining conjugate stability, optimizing conjugation ratios, and separating conjugated from unconjugated species
• Understanding of conjugation chemistry mechanisms and their impact on downstream purification strategies (e.g., hydrophobic interaction chromatography or anion exchange chromatography for conjugate separation)
• Purification development experience with AAV, mRNA, or other gene therapy strategies
• Ability to interact and form dynamic relationships with a wide range of groups
• Experience with process control and documentation systems (Unicorn, Empower, electronic laboratory notebooks)
• General interpersonal and communication skills; mentoring, feedback, training, and cultivating an environment for learning and open/honest communication.
• Basic analytical skills and understanding
• Advanced problem-solving skills.

Additional Information

Physical Demands/Travel

The physical demands of this job are consistent with a lab environment.

Work Environment

This position’s work environment is in a Laboratory environment.