Advisor/Senior Advisor, Purification Development
Eli Lilly and Company
August 08, 2026
On-site
Indianapolis, IN
Operations
Position Summary:
Purification Development Scientist in Bioproduct Research and Development (downstream drug substance processes for purification of monoclonal antibodies, recombinant proteins, viral vectors, bioconjugates, and peptides). Located in Indianapolis.
Responsibilities:
- Identify and develop new purification technologies.
- Design optimized downstream drug substance processes for new biologic candidates.
- Maintain accurate records and interpret data to analyze experiment execution.
- Oversee process and technical transfer to GMP manufacturing facilities (discovery to clinic).
- Write technical reports/tech transfer documents and give presentations.
- Maintain flexibility for new projects and challenges.
- Troubleshoot issues; identify trends and opportunities to reduce process variability.
Basic Requirements:
- PhD in Chemical Engineering or related field focused on biological separation sciences, OR
- MS in Chemistry/Chemical Engineering (or related) with at least 5 years leading protein purification/process development experience, OR
- BS in Chemistry/Chemical Engineering (or related) with at least 8 years leading protein purification/process development experience.
Additional Preferences (preferred):
- Attention to detail; quality-minded experimental design and record keeping.
- Effective oral/written communication; strong laboratory skills.
- Experience purifying complex bioconjugates (e.g., ADCs, PEGylated proteins, antibody-oligonucleotide conjugates).
- Purification development experience with AAV, mRNA, or other gene therapy strategies.
- Extensive membrane filtration knowledge.
- Experience with process control/documentation systems (Unicorn, Empower, electronic lab notebooks).
- Experience interfacing with CDMOs/external partners; late-phase process development (risk assessment, characterization, or regulatory filing).
Benefits:
- Eligible for company bonus (depending on company/individual performance).
- Comprehensive benefits for eligible employees (e.g., 401(k), pension, vacation, medical/dental/vision/prescription; flexible benefits; life insurance; time off/leave; well-being benefits such as EAP and fitness benefits).
Purification Development Scientist in Bioproduct Research and Development (downstream drug substance processes for purification of monoclonal antibodies, recombinant proteins, viral vectors, bioconjugates, and peptides). Located in Indianapolis.
Responsibilities:
- Identify and develop new purification technologies.
- Design optimized downstream drug substance processes for new biologic candidates.
- Maintain accurate records and interpret data to analyze experiment execution.
- Oversee process and technical transfer to GMP manufacturing facilities (discovery to clinic).
- Write technical reports/tech transfer documents and give presentations.
- Maintain flexibility for new projects and challenges.
- Troubleshoot issues; identify trends and opportunities to reduce process variability.
Basic Requirements:
- PhD in Chemical Engineering or related field focused on biological separation sciences, OR
- MS in Chemistry/Chemical Engineering (or related) with at least 5 years leading protein purification/process development experience, OR
- BS in Chemistry/Chemical Engineering (or related) with at least 8 years leading protein purification/process development experience.
Additional Preferences (preferred):
- Attention to detail; quality-minded experimental design and record keeping.
- Effective oral/written communication; strong laboratory skills.
- Experience purifying complex bioconjugates (e.g., ADCs, PEGylated proteins, antibody-oligonucleotide conjugates).
- Purification development experience with AAV, mRNA, or other gene therapy strategies.
- Extensive membrane filtration knowledge.
- Experience with process control/documentation systems (Unicorn, Empower, electronic lab notebooks).
- Experience interfacing with CDMOs/external partners; late-phase process development (risk assessment, characterization, or regulatory filing).
Benefits:
- Eligible for company bonus (depending on company/individual performance).
- Comprehensive benefits for eligible employees (e.g., 401(k), pension, vacation, medical/dental/vision/prescription; flexible benefits; life insurance; time off/leave; well-being benefits such as EAP and fitness benefits).