Advisor - mRNA and circRNA Process Development

Role Summary

Advisor - mRNA and circRNA Process Development

Responsibilities

• Execute process development projects to establish mRNA and circRNA production capabilities at research to pre-clinical scales.
• Produce RNA samples to support internal and external collaborations.
• Design and perform routine biochemistry experiments, including in vitro transcription, purification, quality evaluation, etc.
• Collaborate with CMC and production teams to harmonize pre-clinical and clinical grade production technology and quality metrics.
• Develop and utilize strategies to synthesize and modify RNA molecules to achieve desired properties.
• Clearly communicate results and recommendations to collaborators, colleagues, managers, and senior management, leading project decision-making.
• Contribute to the company‚Äôs intellectual property portfolio by generating new ideas, recommending technical strategy, reading broadly in relevant fields, and diligently maintaining organized records.

Qualifications

• Ph.D. in Chemistry, Molecular Biology, Biochemistry, Biotechnology, or related scientific discipline with 1+ years of academic or pharmaceutical industry experience in mRNA or circRNA process development. Alternatively, a Masters degree with 12+ years of relevant post-graduate work experience, or a Bachelors degree with 15+ years of relevant post-graduate work experience.
• In-depth understanding and hands-on experience with RNA chemistry.
• Expertise with production and characterization of mRNA or circRNA molecules using state-of-the-art techniques.
• Expertise with different approaches for RNA modification and their application in mRNA or circRNA therapeutics.
• Experience and understanding of technical challenges with mRNA or circRNA as a therapeutic modality. Experience with several mRNA modalities (linear mRNA, saRNA, circRNA, etc.) is a plus.
• Strong organizational, communication, and interpersonal skills, and ability to work independently and in a collaborative environment.
• User-level experience with automated liquid handlers is a plus.
• Familiarity with Design-of-Experiments (DOE) is a plus.
• Relevant publication record in academic and/or patent literature is a plus.

Skills

• RNA chemistry
• mRNA synthesis and purification
• Biochemistry experimentation (in vitro transcription, purification, quality evaluation)
• Communication and collaboration
• Project leadership and decision-making
• Intellectual property development

Education

• Ph.D. in Chemistry, Molecular Biology, Biochemistry, Biotechnology, or related field (or equivalent combination of education and experience as noted in Qualifications).